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β-Elemene

Catalog No. T13476 CAS 515-13-9

Synonyms: (-)-β-Elemene, Levo-β-elemene

β-Elemene (Levo-β-elemene) is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.

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β-Elemene, CAS 515-13-9

Pack Size	Availability	Price/USD
20 mg	In stock	$ 68.00
100 mg	In stock	$ 166.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.35%

Purity: 97.06%

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Description	β-Elemene (Levo-β-elemene) is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.
In vitro	β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro.?Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition.?β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9.?β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression.?Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment.?β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis[3].
Cell Research	Cell viability assay was used to assess the resistance of SGC7901/ADR cells and the cytotoxic effects of β-Elemene.?Wound healing, transwell assay and lung metastatic mice model were used to the anti-metastasis effects of β-Elemene.?MicroRNA microarray analysis was used to explore potential regulated miRNAs.?Luciferase reporter assay was used to identify the direct target.?Human MMP antibody array, western blot, immunoprecipitation, qRT-PCR analyses and immunohistochemistry were conducted to investigate the underlying anti-metastasis mechanism of β-Elemene[3].
Source	Natural Products > Zingiberaceae > Curcuma

Synonyms	(-)-β-Elemene, Levo-β-elemene
Molecular Weight	204.35
Formula	C15H24
CAS No.	515-13-9

Storage

store under nitrogen

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (244.68 mM), Sonication is recommended.

References and Literature

1. Ross, S.A., and ElSohly, M.A. The volatile oil composition of fresh and air-dried buds of Cannabis sativa. J. Nat. Prod. 59(1), 49-51 (1996). 2. Gan D, et al. β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway.Oncol Lett. 2020 Jan;19(1):291-300.

Citations

1. Wang J, Qian C, Chen Y, et al.β-elemene alleviates hyperglycemia-induced cardiac inflammation and remodeling by inhibiting the JAK/STAT3-NF-κB pathway.Phytomedicine.2023: 154987.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Miao medicine Compound Library Tobacco Monomer Library Anti-Cancer Active Compound Library Traditional Chinese Medicine Monomer Library Drug Repurposing Compound Library Chinese Pharmacopoeia Natural Product Library RO5 Drug-like Natural Product Library Bioactive Compounds Library Max

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Keywords

β-Elemene 515-13-9 Apoptosis Levo-b-elemene Inhibitor beta-Elemene (-)-β-Elemene inhibit Levo-beta-elemene β Elemene Levo-β-elemene βElemene b-Elemene inhibitor

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