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Search Results for " α7nachr "

11

Compounds

Cat No. Product Name Synonyms Targets
T6950 PNU-120596 NSC 216666 AChR
PNU-120596 (NSC-216666) is a positive allosteric modulator of α7 nAChR with EC50 of 216 nM.
T12017 Methyllycaconitine citrate MLA AChR
Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier.
T8868 4BP-TQS AChR
4BP-TQS is an allosteric agonist of α7 nAChRs.
T9172 Simufilam dihydrochloride PTI-125 dihydrochloride Others
Simufilam dihydrochloride (PTI-125 dihydrochloride) is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds a...
T7884 NS 1738 NSC 213859 AChR
NS 1738 (NSC-213859) is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs)
T71398 RO5126946
RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay...
T80471 α-Conotoxin MrIC
α-Conotoxin MrIC is a biased agonist selective for the α7 nicotinic acetylcholine receptor (nAChR), with activation contingent upon the presence of type II positive allosteric modulators, such as PNU120596. It is utilize...
T12525 Pozanicline dihydrochloride ABT-089 dihydrochloride AChR
Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable agonist of nicotinic acetylcholine receptor (nAChR) (Ki = 16.7 nM)
T75875 α-Conotoxin PnIA TFA
α-Conotoxin PnIA TFA, a potent and selective antagonist of the mammalian α7 nAChR, holds promise for neurological research, particularly in studying neuropathic pain and Alzheimer's disease [1].
T75309 R-(+)-Cotinine
R-(+)-Cotinine ((+)-Cotinine), a metabolite of Nicotine, demonstrates minimal activity across numerous pharmacological targets. However, it is capable of enhancing the acetylcholine (Ach)-evoked current in human α7 nicot...
T80460 Azemiopsin
Azemiopsin, a potent inhibitor of the nicotinic acetylcholine receptor (nAChR), demonstrates half maximal inhibitory concentrations (IC50s) of 0.18 μM for T. californica nAChR and 22 μM for human α7 nAChR. Moreover, it e...
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