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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T72410 | Sortilin antagonist 1 | ||
Sortilin Antagonist 1, a potent sortilin antagonist, exhibits an inhibition constant (IC50) of 20 nM against Neurotensin (NTS) binding to sortilin. Neurotensin acts as a sortilin ligand. This compound is utilized in neur... | |||
T9044 | SORT-PGRN interaction inhibitor 1 | Neurotensin Receptor | |
SORT-PGRN interaction inhibitor 1 is a potent sortilin-progranulin interaction inhibitor(IC50 of 2 μM). | |||
TQ0086 | AF38469 | AF-38469 | Neurotensin Receptor |
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM). | |||
T77053 | Latozinemab | GSK-4527223,AL-001 | Neurotensin Receptor |
Latozinemab (AL001) is a potent and selective recombinant humanized monoclonal antibody against Sortilin.Latozinemab has a high affinity for Sortilin and interrupts the interaction between the granule protein precursor (... | |||
T13530 | AF40431 | Others | |
AF40431 is the first reported small-molecule ligand of sortilin (IC50: 4.4 µM; Kd: 0.7 µM). AF40431 is bound in the neurotensin-binding site of sortilin. | |||
T70971 | VGD020 | ||
VGD020 is a CD4 and sortilin inhibitor. It displayed activity for sortilin down-modulation and reduction of progranulin-induced breast cancer stem cell propagation. | |||
T64206 | VGD071 | ||
VGD071, a compound that targets sortilin, presents a promising avenue for forthcoming research utilizing mouse models of breast cancer. |