Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 107.00 | |
5 mg | In stock | $ 228.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 253.00 |
Description | AF38469 is a new, specific and orally bioavailable Sortilin inhibitor (IC50: 330 nM). |
Targets&IC50 | Sortilin:330 nM |
In vitro | AF38469 showed no inhibition or stimulation of >50% at 10 μM in a standard selectivity panel of ca. 70 targets run at CEREP. Importantly AF38469 showed no activity against the NTR1 receptor. In addition, AF38469 showed no activity against a selected panel of targets known to bind acidic molecules (d-Opioid, GPR40, PPARd, EP1, Angiotensin AT1, Endothelin ETA & B, MMP-12). AF38469 will serve as an important tool to further delineate the biology of Sortilin, and to facilitate the evaluation of the therapeutic potential of this protein. |
Synonyms | AF-38469 |
Molecular Weight | 324.25 |
Formula | C15H11F3N2O3 |
CAS No. | 1531634-31-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (123.36 mM)
You can also refer to dose conversion for different animals. More
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AF38469 1531634-31-7 GPCR/G Protein Neurotensin Receptor inhibit Inhibitor AF 38469 AF-38469 inhibitor