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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9111 | 8-Azaadenosine | Adenosine deaminase | |
8-Azaadenosine, a powerful ADAR1 (ADAR1) and A-to-I editing inhibitor, effectively blocks RNA editing and suppresses proliferation, 3D growth, invasion, and migration in thyroid cancer cells. | |||
T40153 | BAMEA-O16B | BAMEA-O16B | |
BAMEAO16B is a lipid nanoparticle that incorporates disulfide bonds for efficient delivery of Cas9 mRNA and sgRNA into cells. In the intracellular environment, BAMEAO16B responds to reduction by releasing RNA, facilitati... | |||
T60520 | Cas9-IN-3 | ||
Cas9-IN-3 is a potent inhibitor of Cas9 with IC50 of 28 μM. CRISPR/Cas systems have revolutionized gene editing in several species [1]. | |||
T74445 | ZA3-Ep10 | ||
ZA3-Ep10, a zwitterionic lipid, is utilized in the formulation of lipid nanoparticles for RNA delivery in vivo and non-viral CRISPR/Cas gene editing applications. | |||
T38320 | 93-O17S | 93-O17S | |
93-O17S is a chalcogen-containing cationic lipidoid.1It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing ... | |||
T79763 | UNC9512 | DNA/RNA Synthesis | |
UNC9512 is a potent antagonist of the methyl-lysine reader protein 53BP1, which can be utilized to investigate the function of 53BP1 in DNA repair, gene editing, and tumorigenesis [1]. | |||
T38319 | 93-O17O | 93-O17O | |
93-O17O is a chalcogen-containing cationic lipidoid.1,2It has been used in the generation of lipid nanoparticles (LPNs). LPNs containing 93-O17O localize to the spleen after intravenous injection into mice.1LPNs containi... | |||
T74879 | 306-N16B | ||
306-N16B is a lipid nanoparticle designed for the systemic co-delivery of Cas9 mRNA and sgRNA, facilitating the transport of mRNA to pulmonary endothelial cells. This compound is advantageous for research focused on geno... | |||
T72764 | 8-Azanebularine | ||
8-Azanebularine, a chemical compound substituting hydrogen for the C6 amino group, effectively inhibits the ADAR2 reaction at elevated concentrations (IC50=15 mM), and exhibits high-affinity binding (KD=2 nM) when incorp... |