Powder: -20°C for 3 years
In solvent: -80°C for 2 years
8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. It blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells.
Description | 8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. It blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells. |
In vitro | 8-azaadenosine (8-aza-AR) was a potent inhibitor of purine synthesis de novo, but 8-aza-HR, at concentrations much higher than the inhibitory concentration of 8-aza-AR, did not inhibit this process.?In H. Ep. 2 cells, 8-aza-HR blocked the conversion of orotic acid to uridine nucleotides and caused an accumulation of orotidine.?This inhibition of pyrimidine biosynthesis apparently does not contribute significantly to the cytotoxicity of 8-aza-HR because uridine provided no degree of reversal of its inhibition of the growth of cell cultures. |
Molecular Weight | 268.233 |
Formula | C9H12N6O4 |
CAS No. | 10299-44-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 250 mg/mL (932.04 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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8-Azaadenosine 10299-44-2 代谢 Adenosine deaminase thyroid inhibit editing LIN28B invasion proliferation Cal62 migration 8Azaadenosine RNA ADAR1 TPC1 Inhibitor Adenosine Deaminase 8 Azaadenosine inhibitor