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8-Azaadenosine

Catalog No. T9111 CAS 10299-44-2

8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. It blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

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8-Azaadenosine, CAS 10299-44-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

8-Azaadenosine is a potent ADAR1 inhibitor and an A-to-I editing inhibitor. It blocks RNA editing and inhibits proliferation, 3D growth, invasion, and migration in thyroid cancer cells.

In vitro

8-azaadenosine (8-aza-AR) was a potent inhibitor of purine synthesis de novo, but 8-aza-HR, at concentrations much higher than the inhibitory concentration of 8-aza-AR, did not inhibit this process.?In H. Ep. 2 cells, 8-aza-HR blocked the conversion of orotic acid to uridine nucleotides and caused an accumulation of orotidine.?This inhibition of pyrimidine biosynthesis apparently does not contribute significantly to the cytotoxicity of 8-aza-HR because uridine provided no degree of reversal of its inhibition of the growth of cell cultures.

Molecular Weight	268.233
Formula	C9H12N6O4
CAS No.	10299-44-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 250 mg/mL (932.04 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Bennett L L , Allan P W . Metabolism and Metabolic Effects of 8-Azainosine and 8-Azaadenosine[J]. Cancer Research, 1976, 36(11 Pt 1):3917.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Inhibitor Library Anti-Cancer Active Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

Hibifolin 8-Azaadenosine Pentostatin Cladribine Erdosteine

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Keywords

8-Azaadenosine 10299-44-2 代谢 Adenosine deaminase thyroid inhibit editing LIN28B invasion proliferation Cal62 migration 8Azaadenosine RNA ADAR1 TPC1 Inhibitor Adenosine Deaminase 8 Azaadenosine inhibitor

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