20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10340 | Antitrypanosomal agent 2 | Parasite | |
Antitrypanosomal agent 2 shows potent and specific antiparasite activities against Trypanosoma brucei. | |||
T10339 | Antitrypanosomal agent 1 | Parasite | |
Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor (IC50: 3.3 μM). Antitrypanosomal agent 1 inhibits glutathione reductase (IC50: 64.8 μM) and T. brucei (EC50: 1 μM). | |||
T62710 | Antitrypanosomal agent 6 | ||
Antitrypanosomal agent 6 (compound 18a) is a potent antitrypanosomal agent showing good ADME properties. Antitrypanosomal agent 6 is more than twice as active as Nifurtimox against Trypanosoma brucei (T. brucei) with an ... | |||
T62372 | Antitrypanosomal agent 8 | ||
Antitrypanosomal agent 8 (compound 3b) showed a strong antitrypanosomal effect against Trypanosoma brucei (IC50: 0.79 μM). The IC50 value was 80.95 μM. | |||
T83014 | Antitrypanosomal agent 16 | Parasite | |
Antitrypanosomal agent 16 functions as a potent trypanocide, exhibiting an inhibitory concentration 50 (IC50) of 0.04μM against the T. congolense strain IL3000 [1]. | |||
T63167 | Antitrypanosomal agent 7 | ||
The Antitrypanosomal agent 7 (compound 18c) is a potent anti-trypanosome agent and shows good ADME properties. The Antitrypanosomal agent 7 was more than two-fold more active against T. brucei (IC50: 0.71 μM) than Nifurt... | |||
T78978 | Antitrypanosomal agent 13 | Parasite | |
Compound 4b (antitrypanosomal agent 13) is a potent antitrypanosomal with notable trypanocidal and cytotoxic activities, exhibiting GI50 values of 0.18 μM against T. brucei and 8.4 μM for HL-60 [1]. | |||
T72229 | Antitrypanosomal agent 11 | ||
Antitrypanosomal Agent 11 is a chemical compound effective against Trypanosoma cruzi, exhibiting an inhibition concentration (IC 50) of 0.23 μM. | |||
T83013 | Antitrypanosomal agent 17 | Parasite | |
Compound 17 (Compd 7a) exhibits potent antiamastigote activity, demonstrated by its IC50 value of 0.03 μM against the T. congolense strain IL3000 [1]. | |||
T64035 | Antitrypanosomal agent 5 | ||
Antitrypanosal agent 5 is a selective anti-trypanosomal agent that acts on T. brucei (IC50: 1 nM) and HEK293 cells (IC50: 483.3 μM). | |||
T72228 | Antitrypanosomal agent 10 | ||
Antitrypanosomal agent 10, an antitrypanosomal compound, effectively inhibits Trypanosoma cruzi with an IC50 of 0.28 μM. | |||
T72267 | Antitrypanosomal agent 9 | ||
Antitrypanosomal agent 9 is a potent compound with inhibitory activity against T. b. brucei, exhibiting an IC50 of 1.15 μM. It is utilized in research for human African trypanosomiasis (HAT). | |||
T78977 | Antitrypanosomal agent 12 | Parasite | |
Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.22 μM. It induces faster cell swelling in bloodstream-form tr... | |||
T62212 | Antitrypanosomal agent 4 | ||
Antitrypanosomal agent 4 (compound 19) is a potent antitrypanosomal agent that crosses the blood-brain barrier and shows good resistance to Trypanosoma cruzi and T. b. brucei with IC50 values of 1.2 μM and 70 nM respecti... | |||
T79254 | Antitrypanosomal agent 14 | Parasite | |
Antitrypanosomal agent 14 (Compound 1), a potent T. brucei inhibitor with an effective concentration (EC50) of 0.47 μM, also inhibits Tb GSK3 with an inhibitory concentration (IC50) of 12 μM, and is utilized in the resea... | |||
T79316 | Antitrypanosomal agent 15 | Proteasome | |
Antitrypanosomal Agent 15 (Compound 26) is an orally active, brain-penetrant, selective inhibitor of the Trypanosoma cruzi proteasome, exhibiting a pIC50 of 7.4 for T. cruzi and <4 for the human proteasome. It possesses ... | |||
T83012 | Antitrypanosomal agent 18 | ||
Compound 18 (compound 8b), a nitrofuran derivative, exhibits potent in vitro trypanocidal activity, with an IC50 value of 0.03 μM [1]. | |||
T4188 | SDZ285428 | SDZ285-428 | P450 , Parasite , Antifungal |
SDZ285428 is a CYP24A1 inhibitor. | |||
TN1493 | Chrysosplenol D | IL Receptor , NF-κB , JNK | |
Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials. | |||
T2112 | Fexinidazole | HOE 239 | Others , Parasite |
Fexinidazole (HOE 239) is an antiparasitic agent. It has activity against Trypanosoma cruzi, Tritrichomonas foetus, Trichomonas vaginalis, Entamoeba histolytica, Trypanosoma brucei, and Leishmania donovani. The biologica... |