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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6720 | Vatalanib dihydrochloride | CGP-797870 dihydrochloride,ZK-222584 dihydrochloride,Vatalanib 2HCl,PTK787 dihydrochloride,Vatalanib (PTK787) 2HCl,CGP-79787 dihydrochloride | Apoptosis , VEGFR , PDGFR |
Vatalanib dihydrochloride (PTK787 dihydrochloride)(IC50=37 nM) is an inhibitor of VEGFR2/KDR. It exhibits less effective against VEGFR1/Flt-1 and 18-fold against VEGFR3/Flt-4. | |||
T17219 | Vatalanib free base | VEGFR | |
Vatalanib is a VEGFR2/KDR inhibitor (IC50: 37 nM). | |||
T71897 | Vatalanib succinate | ||
Vatalanib succinate is a VEGFR, PDGFR-β, c-Kit, c-Fms, and aromatase inhibitor. | |||
T69888 | SB02024 | ||
SB02024 is a VPS34 inhibitor. SB02024 activates cGAS-STING signaling and sensitizes tumors to STING agonist. SB02024 blocked autophagy in vitro and reduced xenograft growth of two breast cancer cell lines, MDA-MB-231 a... | |||
T69487 | ZK-261557 | ||
ZK-261557 is a new oral antiangiogenic molecule that inhibits all known vascular endothelial growth factor receptors. Vatalanib is under investigation for the treatment of solid tumors. |