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Search Results for " tazemetostat "

7

Compounds

Cat No. Product Name Synonyms Targets
T1788 Tazemetostat E-7438,EPZ6438 Histone Methyltransferase
Tazemetostat (EPZ6438) is a histone methyltransferase EZH2 inhibitor (IC50=11 nM) that is orally active, selective, and SAM-competitive. Tazemetostat exhibits antitumor activity and may be used for the treatment of epith...
T17002 Tazemetostat hydrobromide E-7438 hydrobromide,EPZ-6438 hydrobromide Histone Methyltransferase
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 (Ki: 2.5 n...
T70588 Tazemetostat HCl
Tazemetostat HCl is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of...
T15240 Tazemetostat trihydrochloride EPZ-6438 trihydrochloride,E-7438 trihydrochloride Histone Methyltransferase
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing wild-type EZH2 (Ki: 2.5 nM). It inhibits EZH2 (IC50s: 11 an...
T77940 Tazemetostat de(methyl morpholine)-COOH Ligands for Target Protein for PROTAC
Tazemetostat de(methyl morpholine)-COOH (compound 7), a PROTAC ligand for EZH2, facilitates the synthesis of PROTACs that target this enzyme. These EZH2 degraders exhibit potent inhibition of cell viability in diffuse la...
T74554 Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].
T70586 S 2720
S 2720 is a human immunodeficiency virus type 1 (HIV-1)-specific reverse transcriptase (RT) inhibitor quinoxaline.
TargetMol