tacrine — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21439	Tacrine	CS 12602,Tacrinum,Tetrahydroaminocrine	AChR
	Tacrine (CS 12602) is an indirect cholinergic agonist and centrally acting anticholinesterase. It is approved for the treatment of Alzheimer's disease.		AChR
T2191	Tacrine hydrochloride (hydrate)	Tacrine,Tacrine hydrochloride hydrate,Tetrahydroaminacrine,Tetrahydroaminoacridine	AChR , AChE
	Tacrine hydrochloride hydrate (Tetrahydroaminacrine) is a cholinesterase inhibitor that crosses the blood-brain barrier. Tacrine has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and i...		AChR , AChE
T22435	Tacrine hydrochloride	Tacrine HCl	Others
	Tacrine is a indirect cholinergic agonist and centrally acting anticholinesterase. Tacrine hydrochloride hydrate is an inhibitor of acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respecti...		Others
T22048	Bis(7)-Tacrine
	Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine with a potential to treat Alzheimer's disease. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA...
T21556	Hydroxytacrine maleate	Velnacrine maleate,HP 029 maleate	AChE
	Hydroxytacrine maleate (Velnacrine maleate) is a cholinesterase (cholinesterase) inhibitor that enhances memory in rodents and may be used in the study of Alzheimer's dementia of the Alzheimer type (SDAT).		AChE
T15132	Dimetacrine	Dimethacrine	Others
	Dimetacrine is a useful antidepressant.		Others
T29481	7-Bromotacrine
	7-Bromotacrine is a biochemical.
T15132L	Dimetacrine tartrate	Linostil,Istonil,Istonyl,Miroistonil,MO 709
	Dimetacrine tartrate is a tricyclic antidepressant (TCA) used for the therapy of depression in Europe and formerly in Japan.
T5S1025	Picfeltarraenin IA	Picfeltarraenin A	AChE
	1. Picfeltarraenin IA (Picfeltarraenin A), IB, IV, X, XI are stronger AChE inhibitions than the known AChE inhibitor Tacrine.		AChE
TN2067	Picfeltarraegenin X	Picfeltarraenin X	AChR
	Picfeltarraenin X shows stronger AChE inhibition than the known AChE inhibitor Tacrine.		AChR
T35975	6,9-Dichloro-1,2,3,4-tetrahydroacridine
	6,9-Dichloro-1,2,3,4-tetrahydroacridine is a synthetic intermediate in the synthesis of tacrine-based acetylcholinesterase (AChE) inhibitors.1It is also an intermediate in the synthesis of multifunctional tacrine hybrids...
TN4711	Onitin		Others
	Onitin shows super-oxide and DPPH free radical scavenging effects.It also exhibits hepatoprotective activity on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells.		Others
T73245	AChE-IN-9
	AChE-IN-9, a Tacrine glycoconjugate connected to acetylated β-Glucose, acts as an AChE inhibitor, demonstrating an IC 50 value of 0.4 μM and exhibiting reduced hepatotoxicity in healthy cells. This compound finds use in ...
TN2487	1,3,5,6-Tetrahydroxyxanthone		Others
	1,3,5,6-Tetrahydroxyxanthone shows moderate hepatoprotective activity with EC(50) values of 160.2 +/- 0.6 microM against tacrine-induced cytotoxicity in HepG2 cells. It can inhibit angiotensin-I-converting-enzyme activit...		Others
TN5154	Torilolone		Others
	Torilin and torilolone show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 values are 20.6 +/- 1.86 and 3.6 +/- 0.1 microM, respectively; and silybin as a positive c...		Others
T63144	ZLMT-12
	ZLMT-12 (compound 35) is a tacrine derivative and a potent inhibitor of CDK2 (IC50: 0.011 μM) and CDK9 (IC50: 0.002 μM). ZLMT-12 weakly inhibits AChE (IC50: 19.023 μM) and BuChE (IC50: 2.768 μM). ZLMT-12 has anti-prolife...