trem2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T62750	TREM2 agonist-2		Others
	TREM2 agonist-2 (I-192) is an orally active and potent myeloid triggered receptor 2 (TREM2) agonist for the study of neurodegenerative diseases.		Others
T62502	TREM2 agonist-1
	TREM2 agonist-1 (I-246) is a triggering receptor expressed on myeloid cells-2 (TREM2) agonist (EC50: 3.0 μM-100 μM).
T62750L	Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine		Others
	rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine has an EC50 value of ≤ 0.05 μM and an E.max value of > 250 μM for TREM2.		Others
T82077	Iluzanebart
	Iluzanebart is a human IgG1κ monoclonal antibody that selectively targets TREM2—a triggering receptor expressed on myeloid cells [1].
T83779	EP4 Antagonist 14	Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14
	EP4 antagonist 14 is a prostaglandin E2 receptor subtype EP4 antagonist, demonstrating an IC50 of 1.1 nM in a HEK293 human receptor reporter assay and blocking β-arrestin recruitment due to PGE2 with an IC50 of 0.9 nM. A...

Compounds

TREM2 agonist-2

T62750

Rel-5-(4-Chloro-2-fluorophenyl)-2,3-dimethyl-7-[(2R,4S)-tetrahydro-2-(1-methyl-1H-pyrazol-4-yl)-2H-pyran-4-yl]pyrido[3,4-b]pyrazine

Synonym: Prostaglandin E2 Receptor 4 Antagonist 14,PGE2 Receptor 4 Antagonist 14

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPK-00507	TREM2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2 consists of a 156 amino acid (aa) extracellular domain (ECD) w...
TMPJ-00117	TREM-2 Protein, Human, Recombinant (mFc)	Human	HEK293 Cells
	TREM-2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 50-65 KDa and the accession number is Q9NZC2.
TMPJ-00115	TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	HEK293 Cells
	TREM-2 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 mammalian cells with C-Avi-6xHis tag. The predicted molecular weight is 30-40 KDa and the accession number is Q9NZC2.
TMPY-01148	TREM-2 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	TREM-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.9 kDa and the accession number is Q5TCX1.
TMPY-00432	TREM-2 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293 Cells
	TREM-2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.4 kDa and the accession number is Q99NH8-1.
TMPY-01703	TREM-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	TREM-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18 kDa and the accession number is Q99NH8-1.
TMPY-06566	TREM-2 Protein, Human, Recombinant (hFc)	Human	HEK293 Cells
	TREM-2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 44.16 kDa and the accession number is NP_061838.1.
TMPY-06598	TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293 Cells
	TREM-2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 20.69 kDa and the accession number is NP_061838.1.