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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21824 | Sephin1 | NSC 65390,IFB-088 | Phosphatase |
Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α | |||
T69440 | Sephin1 Hydrochloride | ||
Sephin1 hydrochloride is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A), which prolongs the benefit of eIF2α phosphorylation, thereby protecting cells from proteostatic defects. | |||
T111959 | IFB-088 acetate | ||
IFB-088 acetate, a benzyl guanidine derivative, is used to treat diseases and cancers associated with the PPP1R15A pathway and associated with protein misfolding stress, Examples include tau disease, synaptic riboprotein... | |||
T9174 | Icerguastat | Sephin 1,lcerguastat,IFB-088 | Phosphatase |
Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo. |