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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12978 | NSC-70220 | SOS1-IN-1 | Raf |
SOS1-IN-1 is an inhibitor of SOS1. | |||
T79162 | SOS1/KRAS-IN-1 | Ras | |
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1]. | |||
T73164 | SOS1-IN-15 | ||
SOS1-IN-15 is an orally active SOS1 inhibitor with an IC 50 of 5 nM. SOS1-IN-15 is a promising drug candidate for the research of KRAS-driven cancer . | |||
T62003 | SOS1-IN-13 | ||
SOS1-IN-13 is a potent inhibitor of son of sevenless homolog 1 (SOS1). SOS1-IN-13 shows IC 50 s of 6.5 nM and 327 nM for SOS1 and pERK, respectively. SOS1-IN-13 has research value in anticancer. | |||
T61963 | SOS1-IN-3 | ||
SOS1-IN-3 is an effective inhibitor of SOS1 (son of sevenless homolog 1) (IC50=5 nM). SOS1-IN-3 shows antitumor activity. | |||
T63201 | SOS1 activator 1 | ||
SOS1 activator 1 is an activator of SOS1-mediated nucleotide exchange (Kd: 44 nM).SOS1 is a guanine nucleotide exchange factor that binds to Ras proteins and catalyzes the exchange of GDP for GTP on RAS, resulting in the... | |||
T74356 | PROTAC SOS1 degrader-2 | ||
PROTAC SOS1 degrader-2, a potent degrader of PROTAC SOS1, effectively reduces the expression of pERK and RAS-GTP in a dose-dependent manner. It significantly inhibits tumor growth in vivo [1]. | |||
T79183 | SOS1-IN-16 | Ras | |
SOS1-IN-16 (Comp 54) serves as a selective SOS1 inhibitor exhibiting an IC50 value of 7.2 nM and demonstrates inhibitory activity against CYP3A4 with an IC50 of 8.9μM when testosterone is employed as a substrate. This co... | |||
TP2116 | SAH-SOS1A | ||
KRas/son of sevenless 1 (SOS1) interaction inhibitor. Binds within nucleotide binding pocket of KRas (Kd values are 106 - 176 nM for wild type KRas and various KRas mutants). Inhibits nucleotide binding to KRas in a conc... |