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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6049 | SNS-032 | SNS032,BMS-387032 | Apoptosis , GSK-3 , CDK |
SNS-032 (BMS-387032) is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and no effect on CDK6. | |||
T17069 | THAL-SNS-032 | CDK | |
THAL-SNS-032 is a selective CDK9 degrader PROTAC. | |||
T79606 | CAF-382 | CDK | |
CAF-382 (compound B1), an analog of SNS-032, functions as a CDKL5 and pan-CDK inhibitor, exhibiting modest inhibitory activity against GSK3α/β with an affinity greater than 1.8 μM. It effectively inhibits CDKL5 and imped... | |||
T83936 | LL-K9-3 | ||
LL-K9-3, a selective hydrophobic tagging technology (HyT)-based degrader, specifically targets the CDK9-cyclin T1 complex, displaying DC50 values of 589 nM for cyclin T1 and 662 nM for CDK9. This compound consists of the... | |||
T77959 | Thalidomide-5-O-C12-NH2 hydrochloride | ||
Thalidomide-5-O-C12-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, when linked to a ligand for protein, forms PROTACs [1]. | |||
T77984 | Thalidomide-NH-C10-NH2 hydrochloride | ||
Thalidomide-NH-C10-NH2 hydrochloride, a thalidomide-derived cereblon ligand, facilitates CRBN protein recruitment and, when conjugated with a linker, forms PROTACs [1]. | |||
T77952 | Thalidomide-5-O-C5-NH2 hydrochloride | ||
Thalidomide-5-O-C5-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1]. | |||
T77950 | Thalidomide-5-O-C3-NH2 hydrochloride | ||
Thalidomide-5-O-C3-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1]. | |||
T77962 | Thalidomide-4-O-C11-NH2 hydrochloride | ||
Thalidomide-4-O-C11-NH2 hydrochloride is a thalidomide-based cereblon ligand for CRBN protein recruitment. It can be conjugated to a protein ligand via a linker to create PROTACs [1]. | |||
T77977 | Thalidomide-5-PEG6-NH2 hydrochloride | ||
Thalidomide-5-PEG6-NH2 hydrochloride, a Thalidomide-derived cereblon ligand, facilitates the recruitment of the CRBN protein and can be tethered to a ligand for protein conjugation via a linker to construct PROTACs [1]. | |||
T77958 | Thalidomide-5-O-C11-NH2 hydrochloride | ||
Thalidomide-5-O-C11-NH2 hydrochloride, a thalidomide-derived cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated to a protein ligand via a linker to synthesize PROTACs [1]. | |||
T77978 | Thalidomide-5-PEG7-NH2 hydrochloride | ||
Thalidomide-5-PEG7-NH2 hydrochloride is a Thalidomide-based cereblon ligand employed for CRBN protein recruitment. It can be conjugated to a protein ligand using a linker to create PROTACs [1]. | |||
T77957 | Thalidomide-5-O-C10-NH2 hydrochloride | ||
Thalidomide-5-O-C10-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, when linked to a protein ligand, forms PROTACs [1]. | |||
T77964 | Thalidomide-4-O-C14-NH2 hydrochloride | ||
Thalidomide-4-O-C14-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and, through the attachment of a linker, can be utilized to create PROTACs [1]. | |||
T77954 | Thalidomide-5-O-C7-NH2 hydrochloride | ||
Thalidomide-5-O-C7-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates CRBN protein recruitment. This compound can be tethered to a protein-targeting ligand using a linker, enabling the formation of PROTA... | |||
T77963 | Thalidomide-4-O-C12-NH2 hydrochloride | ||
Thalidomide-4-O-C12-NH2 hydrochloride is a cereblon ligand based on Thalidomide, utilized for recruiting the CRBN protein. This compound can be tethered to a protein ligand using a linker, enabling the formation of PROTA... | |||
T77919 | Thalidomide-4-O-C10-NH2 hydrochloride | ||
Thalidomide-4-O-C10-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of the CRBN protein. This compound can be conjugated with a protein ligand via a linker to synthesize PROTACs [1]. | |||
T77917 | Thalidomide-4-O-C7-NH2 hydrochloride | ||
Thalidomide-4-O-C7-NH2 hydrochloride, a Thalidomide-based cereblon ligand, plays a role in the recruitment of CRBN protein and, when linked to a protein ligand, forms PROTACs [1]. | |||
T77949 | Thalidomide-5-O-C2-NH2 hydrochloride | ||
Thalidomide-5-O-C2-NH2 hydrochloride, a Thalidomide-based cereblon ligand, facilitates the recruitment of CRBN protein and can be conjugated via a linker to form PROTACs [1]. | |||
T77961 | Thalidomide-5-O-C14-NH2 hydrochloride | ||
Thalidomide-5-O-C14-NH2 hydrochloride, a cereblon ligand based on Thalidomide, facilitates the recruitment of CRBN protein. By incorporating a linker, this compound can be conjugated to a ligand to create PROTACs [1]. |