5
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4459 | PK11000 | DNA Alkylator/Crosslinker | |
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53. | |||
T14554 | BI-0252 | Others | |
BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM). BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of a... | |||
T26610 | AM-6761 | AM 6761,AM6761 | |
AM-6761 is a potent inhibitor of the MDM2-p53 interaction. In the SJSA-1 osteosarcoma xenograft model, AM-6761 shows excellent antitumor activity with an ED50 of 11 mg/kg. | |||
T73895 | MI-1061 TFA | ||
MI-1061 TFA, a potent and orally bioavailable MDM2 inhibitor (MDM2-p53 interaction), demonstrates significant chemical stability with an IC 50 of 4.4 nM and a K i of 0.16 nM. It effectively activates p53 and induces apop... | |||
T78753 | Aurora Kinases-IN-4 | Aurora Kinase | |
Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM. It demonstrates cell proliferation inhibition in SJSA-1, MDA-MB-231, A549, and HeLa cell lines ... |