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Search Results for " sjsa-1 "

5

Compounds

Cat No. Product Name Synonyms Targets
T4459 PK11000 DNA Alkylator/Crosslinker
PK11000 is a p53 targeting compound, has anti-tumor activities through activation of unstable p53.
T14554 BI-0252 Others
BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM). BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of a...
T26610 AM-6761 AM 6761,AM6761
AM-6761 is a potent inhibitor of the MDM2-p53 interaction. In the SJSA-1 osteosarcoma xenograft model, AM-6761 shows excellent antitumor activity with an ED50 of 11 mg/kg.
T73895 MI-1061 TFA
MI-1061 TFA, a potent and orally bioavailable MDM2 inhibitor (MDM2-p53 interaction), demonstrates significant chemical stability with an IC 50 of 4.4 nM and a K i of 0.16 nM. It effectively activates p53 and induces apop...
T78753 Aurora Kinases-IN-4 Aurora Kinase
Aurora Kinases-IN-4 (Compound 11c) is a covalent, ATP-competitive inhibitor of aurora kinase A with an IC50 value of 1.7 nM. It demonstrates cell proliferation inhibition in SJSA-1, MDA-MB-231, A549, and HeLa cell lines ...
TargetMol