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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T12730 | RIPK1-IN-4 | RIP kinase | |
RIPK1-IN-4 is a potent and selective type II kinase receptor interacting protein 1 (RIP1) kinase inhibitor and binds to a DLG-out inactive form of RIP1 (IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase). | |||
T9095 | Necrostatin-34 | 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 | RIP kinase |
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain. | |||
T12731 | RIPK1-IN-7 | RIP kinase | |
RIPK1-IN-7 is a potent and selective inhibitor of RIPK1(Kd of 4 nM and an enzymatic IC50 of 11 nM),andexhibits excellent antimetastasis activity in the experimental B16 melanoma lung metastasis model. | |||
T63469 | RIPK1-IN-8 | ||
RIPK1-IN-8 is an aminoimidazolopyridine and is a selective and potent inhibitor of RIPK1 (IC50: 4 nM).RIPK1-IN-8 has research potential in inflammatory diseases. |