Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 289.00 | |
25 mg | In stock | $ 537.00 | |
50 mg | In stock | $ 775.00 | |
100 mg | In stock | $ 1,080.00 | |
500 mg | In stock | $ 2,170.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 229.00 |
Description | Necrostatin-34 (2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4) is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain. |
In vitro | Necrostatin-34 (10?μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation. Necrostatin-34 may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase. Necrostatin-34 shows IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively. |
Synonyms | 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 |
Molecular Weight | 384.48 |
Formula | C18H16N4O2S2 |
CAS No. | 375835-43-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (325.11 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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Necrostatin-34 375835-43-1 Apoptosis NF-Κb RIP kinase Necrostatin 34 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 FADD RIPK inhibit RIPK1 Receptor-interacting protein kinases p-S166 Necroptosis Necrostatin34 Inhibitor inhibitor