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Necrostatin-34

Catalog No. T9095 CAS 375835-43-1

Synonyms: 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4

Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.

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Necrostatin-34, CAS 375835-43-1

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Purity: 98%

Biological Description

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Storage & Solubility Information

Description	Necrostatin-34 is a RIPK1 kinase inhibitor, stabilizing RIPK1 kinase in an inactive conformation by occupying a distinct binding pocket in the kinase domain.
In vitro	Necrostatin-34 (10?μM) inhibits the dimerization-induced RIPK1 activation as examined by phosphorylation of Ser166 (p-S166) of RIPK1, a biomarker for RIPK1 activation. Necrostatin-34 may block TNFα-induced complex II formation by inhibiting the activation of RIPK1 kinase. Necrostatin-34 shows IC50 values of 667 nM and 134 nM for TNFα in FADD def-Jurkat cells and L939 cells, respectively.

Synonyms	2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4
Molecular Weight	384.48
Formula	C18H16N4O2S2
CAS No.	375835-43-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 125 mg/mL (325.11 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Huyan Meng, et al. Discovery of a cooperative mode of inhibiting RIPK1 kinase. Cell Discov. 2021 Jun 1;7(1):41.

Related Products

Related compounds with same targets

Eclitasertib RIPA-56 GSK547 HS-1371 GSK-872 Necrostatin-5 GSK3145095 RIPK1-IN-4

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Necrostatin-34 375835-43-1 NF-Kb信号通路凋亡 RIP kinase Necrostatin 34 FADD RIPK inhibit RIPK1 Receptor-interacting protein kinases 2-{[3-cyano-4-(4-methylphenyl)-6-oxo-1,4 p-S166 Necroptosis Necrostatin34 Inhibitor inhibitor

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