ret — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9673	RET-IN-3		c-RET
	RET-IN-3 is a RETV804M kinase inhibitor with potential anticancer activity for the study of non-small cell lung cancer.		c-RET
T8467	RET V804M-IN-1	RETV804M kinase inhibitor,LUN09945	c-RET
	RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).		c-RET
T40097	RET-IN-4
	RET-IN-4 is a highly effective and specific RET inhibitor that can be administered orally. It demonstrates remarkable potency, with IC50 values of 1.29 nM, 1.97 nM, and 0.99 nM for inhibiting RET variants including RET (...
T69644	DUN73423	RET-IN-21	c-RET
	DUN73423 (RET-IN-21) is a potent tyrosine kinase (RET) inhibitor with antitumour activity for the study of cancer.		c-RET
T16735	RET-IN-1		Others
	RET-IN-1 is a RET kinase inhibitor (IC50s: 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively).		Others
T63772	RET-IN-5
	RET-IN-5 is a potent inhibitor of RET (IC50: 4.57 nM).
T63877	RET-IN-17
	RET-IN-17 is a potent inhibitor of RET. RET-IN-17 has potential for studies of pain associated with IBS and other gastrointestinal disorders, as well as cancers with constitutive RET kinase activity.
T79163	RET-IN-24
	RET-IN-24 (Compound 26) is a selective inhibitor of RET tyrosine kinase, demonstrating antitumor activity [1].
T78683	RET-IN-22
	RET-IN-22 (compound 17b) is a potent, selective, and orally active inhibitor of RET, exhibiting IC50 values of 20.9 nM for wild-type RET and 18.3 nM for RET-V804M. It demonstrates a highly selective inhibition profile ac...
T63358	RET-IN-15
	RET-IN-15 is an inhibitor of rearrangement kinase (RET) during transfection and can be used in cancer research.
T73256	RET-IN-16
	RET-IN-16 is a potent, selective inhibitor of RET, exhibiting IC50 values of 3.98 nM for RET(WT), 8.42 nM for RET(M918T), 15.05 nM for RET(V804L), 7.86 nM for RET(V804M), 5.43 nM for RET-CCDC6, and 8.86 nM for RET-KIF5B,...
T63249	RET-IN-6
	RET-IN-6 is a potent inhibitor of RET (IC50: 4.57 nM).
T63583	RET-IN-11
	RET-IN-11 is a potent and selective RET inhibitor that acts on RET (IC50: 6.20 nM) and RETV804M (IC50: 18.68 nM).RET-IN-11 induces apoptosis.RET-IN-11 exhibits anti-proliferative and migratory effects in LC-2/ad cells. R...
T62877	RET-IN-7
	RET-IN-7 exhibits strong inhibitory effects against RET kinase in vitro and shows significant efficacy in treating RET-driven tumor xenografts in mice through multiple-day dosing.
T81296	RET-IN-26
	RET-IN-26 (compound D5) is a kinase inhibitor that selectively targets the RET protein with an IC50 value of 0.33 μM [1].
T63183	RET-IN-9
	RET-IN-9 is a potent inhibitor of RET. RET kinase is a single-channel transmembrane receptor tyrosine kinase that plays an important role in the development of the kidney and enteric nervous system, as well as in the mai...
T64103	RET-IN-12
	RET-IN-12 is a RET inhibitor capable of acting on RET(WT) (IC50: 0.3 nM) and RET(V804M) (IC50: 1 nM).
T79099	RET-IN-23
	RET-IN-23 (compound 17) is a potent, orally active inhibitor of RET, displaying IC50 values of 1.32 nM for RET-WT, 2.50 nM for RET-CCDC6, 6.54 nM for RET-V804L, 1.03 nM for RET-V804M, and 1.47 nM for RET-M918T. The compo...
T63468	RET-IN-14
	RET-IN-14 is a potent inhibitor of RET, capable of acting on RET (WT) (IC50 < 0.51 nM), RET (G810R) (IC50: 9.3 nM), RET (V804M) (IC50: 1.3 nM), BTK (C481S) (IC50: 9.2 nM) and BTK (C481S) (IC50 : 15 nM). RET-IN-14 exhibit...
T63837	RET-IN-19
	RET-IN-19 is a potent inhibitor of RET and exhibits anticancer effects on RET-wt (IC50: 6.8 nM) and RET V804M (IC50: 13.51 nM).RET-IN-19 can be used to study non-small cell lung cancer (NSCLC).