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RET V804M-IN-1

Name: RET V804M-IN-1
Brand: TargetMol
SKU: T8467
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8467Cas No. 2414909-94-5

Alias RETV804M kinase inhibitor, LUN09945

RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

RET V804M-IN-1

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Purity: 99.62%

Catalog No. T8467Alias RETV804M kinase inhibitor, LUN09945Cas No. 2414909-94-5

RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$45	In Stock	In Stock
5 mg	$72	In Stock	In Stock
10 mg	$97	In Stock	In Stock
25 mg	$168	In Stock	In Stock
50 mg	$263	In Stock	In Stock
100 mg	$372	In Stock	In Stock
200 mg	$549	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.62%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

RET V804M-IN-1 AI Summary

RET V804M-IN-1 exhibits bioactivities related to the inhibition of the recombinant human RET V804M mutant, with an IC50 value of 51.0 nM in a TR-FRET assay. It demonstrates significant selectivity towards the RET V804M mutant over other targets, indicated by selectivity index ratios of 13.0 against human RET and 19.0 against human KDR, both in expression systems. Additionally, the compound shows efficacy in inhibiting the RET V804M mutant expressed in human BaF3 cells, with an IC50 value of 3900.0 nM in a cell viability assay. The selectivity towards RET V804M over wild-type RET and KDR in these cells is highlighted by selectivity index ratios of 0.85 and 1.9, respectively..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	RET V804M-IN-1 (RETV804M kinase inhibitor) is a wt-RET -selective RETV804M kinase inhibitors(IC50 = 20 nM).
Targets&IC50	RET (V804M):20 nM
Synonyms	RETV804M kinase inhibitor, LUN09945

Chemical Properties

Molecular Weight	344.37
Formula	C₁₉H₁₆N₆O
Cas No.	2414909-94-5
Smiles	NC(=O)c1ccc(cc1)-c1cnn2ccc(NCc3cccnc3)nc12
Relative Density.	1.38 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (348.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9039 mL	14.5193 mL	29.0385 mL	145.1927 mL
5 mM	0.5808 mL	2.9039 mL	5.8077 mL	29.0385 mL
10 mM	0.2904 mL	1.4519 mL	2.9039 mL	14.5193 mL
20 mM	0.1452 mL	0.7260 mL	1.4519 mL	7.2596 mL
50 mM	0.0581 mL	0.2904 mL	0.5808 mL	2.9039 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4519 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc