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Search Results for " pwwp1 "

7

Compounds

Cat No. Product Name Synonyms Targets
T8879 MR837 ZINC30303842,NSD2-PWWP1 antagonist 3f Others , Histone Methyltransferase
MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist.
T9584 UNC6934 Others , Histone Methyltransferase
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2.
T10538 BI-9321 Others
BI-9321 is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2.
T10538L BI-9321 trihydrochloride Others
BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2.
T79616 UNC7096 Histone Methyltransferase
UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1].
T62705 NSD2-IN-1
NSD2-IN-1 (compound 38) serves as a potent and highly selective inhibitor of NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1), demonstrating an IC50 value of 0.11 μM. By binding to NSD2-PWWP1, NSD2-IN-1 impacts t...
T79615 MS9715 Histone Methyltransferase
MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligase VHL ligand. This compound holds potential for research in N...
TargetMol