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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8879 | MR837 | ZINC30303842,NSD2-PWWP1 antagonist 3f | Others , Histone Methyltransferase |
MR837 (NSD2-PWWP1 antagonist 3f) is a NSD2-PWWP1 antagonist. | |||
T9584 | UNC6934 | Others , Histone Methyltransferase | |
UNC6934 is a chemical probe targeting the N-terminal PWWP (PWWP1) domain of NSD2. | |||
T10538 | BI-9321 | Others | |
BI-9321 is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. | |||
T10538L | BI-9321 trihydrochloride | Others | |
BI-9321 trihydrochloride is a selective and cellular active nuclear receptor-binding SET domain 3 (NSD3)-PWWP1 domain antagonist (Kd: 166 nM). BI-9321 is inactive against NSD2-PWWP1 and NSD3-PWWP2. | |||
T79616 | UNC7096 | Histone Methyltransferase | |
UNC7096 is a potent, selective degrader of NSD2-PWWP1, exhibiting a dissociation constant (Kd) of 46 nM, and shows promise for treating NSD2-related diseases [1]. | |||
T62705 | NSD2-IN-1 | ||
NSD2-IN-1 (compound 38) serves as a potent and highly selective inhibitor of NSD2-PWWP1 (nuclear receptor-binding SET domain 2-PWWP1), demonstrating an IC50 value of 0.11 μM. By binding to NSD2-PWWP1, NSD2-IN-1 impacts t... | |||
T79615 | MS9715 | Histone Methyltransferase | |
MS9715 is a potent and selective NSD3-targeting PROTAC, designed by leveraging BI-9321, which targets the PWWP1 domain of NSD3, in conjunction with an E3 ligase VHL ligand. This compound holds potential for research in N... |