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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T40254 | MRTX-1719 | Histone Methyltransferase | |
MRTX-1719 is a potent, first-in-class, selective inhibitor of the PRMT5/MTA complex, with an IC50 of less than 10 nM in PRMT5/MTA MTAP DEL SDMA cells. | |||
T9575 | MRTX9768 | Histone Methyltransferase | |
MRTX-9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. | |||
T79873 | TNG-462 | Histone Methyltransferase | |
TNG-462 (Compound 1143) is a PRMT5 inhibitor with oral activity, being investigated for use in MTAP-deficient and/or MTA-accumulating cancers [1]. | |||
T36630 | MRTX9768 hydrochloride | ||
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT... |