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Search Results for " pi3kα-in-14 "

4

Compounds

Cat No. Product Name Synonyms Targets
T81469 PI3Kα-IN-14 PI3K
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in cell cycle arrest at the G1 phase and apoptosis in U87-MG cel...
T1916 Apitolisib RG 7422,GNE 390,GDC-0980 Apoptosis , PI3K , mTOR
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce...
T2619 CH5132799 PI3K , mTOR
CH5132799 has been used in trials studying the treatment of Solid Tumors.
T36085 PKI-179 hydrochloride
PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR). In an in vitro enzymatic assay, it potently inhibits PI3K (IC50s = 8, 24, 17, and 74 nM for isoforms α, β, δ, and γ, resp...
TargetMol