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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T81469 | PI3Kα-IN-14 | PI3K | |
PI3Kα-IN-14 (compound F8), a potent PI3Kα inhibitor, exhibits an IC50 value of 0.14 nM and markedly diminishes mitochondrial membrane potential, resulting in cell cycle arrest at the G1 phase and apoptosis in U87-MG cel... | |||
T1916 | Apitolisib | RG 7422,GNE 390,GDC-0980 | Apoptosis , PI3K , mTOR |
Apitolisib (RG 7422), an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in trials study of solid cancers, breast cancer, prostate cancer, renal ce... | |||
T2619 | CH5132799 | PI3K , mTOR | |
CH5132799 has been used in trials studying the treatment of Solid Tumors. | |||
T36085 | PKI-179 hydrochloride | ||
PKI-179 is an orally bioavailable dual inhibitor of PI3K and mammalian target of rapamycin (mTOR). In an in vitro enzymatic assay, it potently inhibits PI3K (IC50s = 8, 24, 17, and 74 nM for isoforms α, β, δ, and γ, resp... |