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Search Results for " pd0325901 "

4

Compounds

Cat No. Product Name Synonyms Targets
T6189 Mirdametinib PD325901,PD0325901 Apoptosis , MEK , Autophagy
Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity. Mirdametinib exhibits antitumor activity by inhibiting p-ERK1/2 expression and inducing apoptosis.
T40217 PD0325901-O-C2-dioxolane PD0325901-O-C2-dioxolane
PD0325901-O-C2-dioxolane is a chemical compound primarily composed of the MEK inhibitor PD0325901. It can be utilized, in conjunction with either a VHL or CRBN E3 ligase ligand, for the synthesis of MEK1/2 degrader.
T13782 MS432 MEK
MS432 is a highly selective PD0325901-based VHL-recruiting PROTAC degrader for MEK1 and MEK2.
T18668 (S,R,S)-AHPC-Me-C10-Br Others
(S,R,S)-AHPC-Me-C10-Br is a chemically synthesized conjugate that functions as a ligand-linker for E3 ligases. This compound incorporates a VHL E3 ligase linker and MS432, derived from the MEK1/2 inhibitor PD0325901[1].
TargetMol