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Search Results for " p2x7 "

20

Compounds

Cat No. Product Name Synonyms Targets
T81579 P2X7 receptor antagonist-4
Compound 14a (P2X7 receptor antagonist-4) is a P2X7R antagonist with IC50 values of 64.7 nM in humans and 10.1 nM in mice. It inhibits the activation of the NLRP3 inflammasome, which subsequently reduces the expression o...
T73335 P2X7-IN-2
P2X7-IN-2, a P2X7 receptor inhibitor, effectively suppresses IL-Iβ release, demonstrating an inhibitory concentration (IC50) value of 0.01 nM. This compound is utilized in the study of autoimmunity, inflammation, and car...
T62488 P2X7 receptor antagonist-1
P2X7 receptor antagonist-1 is a purinergic P2X7 receptor antagonist with anti-neuroinflammatory effects.
T61566 P2X7 receptor antagonist-2
P2X7 receptor antagonist-2 is a highly potent antagonist of the P2X7 receptor, exhibiting a pIC50 value range of 6.5-7.5. Its efficacy in combating neuroinflammation has been demonstrated [1].
T72198 P2X7 receptor antagonist-3
P2X7 receptor antagonist-3 is a powerful inhibitor of the P2X7 receptor, exhibiting IC50 values of 4.2 nM in humans and 6.8 nM in rats, indicating its high potency in both species.
T75254 P2X7-IN-2 TFA
P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor that demonstrates the capability to inhibit IL-Iβ release effectively with an IC50 value of 0.01 nM. It is utilized in research focused on autoimmunity, inflammati...
T4298 JNJ-47965567 JNJ-479655 P2X Receptor
JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively).
T9786 Lu AF27139 P2X Receptor
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases st...
T14076 A 839977 A839977,A-839977 P2X Receptor , Calcium Channel
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis.
T2673 A 438079 hydrochloride A 438079 (hydrochloride),A-438079 hydrochloride,A-438079 HCl P2X Receptor
A 438079 hydrochloride (A-438079 HCl) is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9.
T10207 A 438079 P2X Receptor
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9).
T27683 JNJ-42253432 P2X Receptor
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels.
T14385 AZD9056 hydrochloride P2X Receptor
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation.
T15622 JNJ-54175446 JNJ-5446 P2X Receptor
JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression.
T3690 A-740003 A 740003 P2X Receptor
A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuro...
T7805 GW791343 dihydrochloride GW791343 (HCl) P2X Receptor
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator.
T61025 GSK-1482160 P2X Receptor
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so G...
TP2226 BzATP triethylammonium salt P2X Receptor
BzATP triethylammonium salt is a P2X7 receptor agonist.
T21659 AZ 11645373 3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE P2X Receptor
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor.
T3639 A-804598 A 804598 P2X Receptor
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human).
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