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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T81579 | P2X7 receptor antagonist-4 | ||
Compound 14a (P2X7 receptor antagonist-4) is a P2X7R antagonist with IC50 values of 64.7 nM in humans and 10.1 nM in mice. It inhibits the activation of the NLRP3 inflammasome, which subsequently reduces the expression o... | |||
T73335 | P2X7-IN-2 | ||
P2X7-IN-2, a P2X7 receptor inhibitor, effectively suppresses IL-Iβ release, demonstrating an inhibitory concentration (IC50) value of 0.01 nM. This compound is utilized in the study of autoimmunity, inflammation, and car... | |||
T62488 | P2X7 receptor antagonist-1 | ||
P2X7 receptor antagonist-1 is a purinergic P2X7 receptor antagonist with anti-neuroinflammatory effects. | |||
T61566 | P2X7 receptor antagonist-2 | ||
P2X7 receptor antagonist-2 is a highly potent antagonist of the P2X7 receptor, exhibiting a pIC50 value range of 6.5-7.5. Its efficacy in combating neuroinflammation has been demonstrated [1]. | |||
T72198 | P2X7 receptor antagonist-3 | ||
P2X7 receptor antagonist-3 is a powerful inhibitor of the P2X7 receptor, exhibiting IC50 values of 4.2 nM in humans and 6.8 nM in rats, indicating its high potency in both species. | |||
T75254 | P2X7-IN-2 TFA | ||
P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor that demonstrates the capability to inhibit IL-Iβ release effectively with an IC50 value of 0.01 nM. It is utilized in research focused on autoimmunity, inflammati... | |||
T4298 | JNJ-47965567 | JNJ-479655 | P2X Receptor |
JNJ-47965567 (JNJ-479655) is a selective antagonist of the purinergic receptor P2X subtype 7 (P2X7), a ligand-gated ion channel(with pKis of 7.9 and 8.7 for human and rat P2X7, respectively). | |||
T9786 | Lu AF27139 | P2X Receptor | |
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases st... | |||
T14076 | A 839977 | A839977,A-839977 | P2X Receptor , Calcium Channel |
A 839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic activity that inhibits BzATP-induced calcium efflux from the P2X7 receptor for the study of renal fibrosis. | |||
T2673 | A 438079 hydrochloride | A 438079 (hydrochloride),A-438079 hydrochloride,A-438079 HCl | P2X Receptor |
A 438079 hydrochloride (A-438079 HCl) is a potent and selective P2X7 receptor antagonist with pIC50 of 6.9. | |||
T10207 | A 438079 | P2X Receptor | |
A 438079 is a potent, and selective antagonist of P2X7 receptor (pIC50: 6.9). | |||
T27683 | JNJ-42253432 | P2X Receptor | |
JNJ-42253432 is an oral active P2X7 antagonist capable of penetrating the central nervous system with a pKi value of 9.1 for rat and 7.9 for human P2X7 channels. | |||
T14385 | AZD9056 hydrochloride | P2X Receptor | |
AZD9056 hydrochloride is a P2X7 inhibitor,Which plays a significant role in pain-causing diseases and inflammation. | |||
T15622 | JNJ-54175446 | JNJ-5446 | P2X Receptor |
JNJ-54175446 (JNJ-5446) is a CNS-permeable and selective P2X7 receptor antagonist that attenuates the release of IL-1β/IL-18 from microglia, and may be used in the study of depression. | |||
T3690 | A-740003 | A 740003 | P2X Receptor |
A-740003 (A 740003) is an effective and specific P2X7 receptor antagonist (IC50: 18/40 nM, for rat/human). It can reduce nociception in animal models of persistent neuropathic and inflammatory pain, and also reduce neuro... | |||
T7805 | GW791343 dihydrochloride | GW791343 (HCl) | P2X Receptor |
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. | |||
T61025 | GSK-1482160 | P2X Receptor | |
GSK-1482160 is a CNS-penetrant negative allosteric modulator of P2X7 receptor with oral activity. The P2X7 receptor is involved in the production of pro-inflammatory cytokines by central and peripheral immune cells, so G... | |||
TP2226 | BzATP triethylammonium salt | P2X Receptor | |
BzATP triethylammonium salt is a P2X7 receptor agonist. | |||
T21659 | AZ 11645373 | 3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE | P2X Receptor |
AZ 11645373 (3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE) is a highly selective and potent human P2X7 receptor antagonist that has no effect on mouse/rat P2X7 receptor. | |||
T3639 | A-804598 | A 804598 | P2X Receptor |
A-804598 is a competitive and selective P2X7 receptor antagonist (IC50: 10 nM, rat; 9 nM, mouse; 11 nM, human). |