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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1703 | SN-38 | NK012,SN 38 | DNA/RNA Synthesis , Topoisomerase , Autophagy |
SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM). SN-38 has antitumor activity and induces autophagy. |