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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3211 | Midostaurin | N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251 | Others , PKC |
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel... | |||
T12036 | Midostaurin-D5 | PKC412-D5,CGP 41251-D5 | Others |
Midostaurin-D5 is a deuterium labeled Midostaurin. | |||
T12610L | 3-Hydroxy Midostaurin | CGP52421 | FLT |
3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of roughly 132 nM in culture medium and 9.8 μM in plasma. Though less selective, it ... | |||
T12280 | O-Desmethyl Midostaurin | CGP62221,O-Desmethyl PKC412 | Others |
O-Desmethyl Midostaurin is the active Midostaurin metabolite via cytochrome P450 liver enzyme metabolism. | |||
T19119 | 3-Hydroxy Midostaurin-D5 | CGP52421-D5 | Others |
3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.... | |||
T12610 | (R)-3-Hydroxy Midostaurin | (R)-CGP52421 | Others |
(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML). | |||
T12791 | (S)-3-Hydroxy Midostaurin | (S)-CGP52421 | Others |
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)). |