Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 3,920.00 | |
50 mg | 10-14 weeks | $ 5,180.00 | |
100 mg | 10-14 weeks | $ 7,300.00 |
Description | (S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)). |
In vitro | (S)-3-Hydroxy Midostaurin(IC50 range of 200-400 nM) against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme. The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ with GI50 of 63 nM, KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive. |
Synonyms | (S)-CGP52421 |
Molecular Weight | 586.64 |
Formula | C35H30N4O5 |
CAS No. | 945260-14-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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(S)-3-Hydroxy Midostaurin 945260-14-0 Others (S) 3 Hydroxy Midostaurin (S)-CGP52421 CGP 52421 CGP-52421 (S)3Hydroxy Midostaurin 3-Hydroxy Midostaurin CGP52421 inhibitor inhibit