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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T61209 | HDAC-IN-27 | ||
HDAC-IN-27 is a potent and orally active inhibitor of HDAC Class I (0.43 nM - 3.01 nM for HDAC1-3). HDAC-IN-27 shows activity against anti-acute myeloid leukemia (AML). | |||
T8517 | Belinostat | PX105684,PXD101,PXD-101 | HDAC , Autophagy |
Belinostat (PXD101) is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity. | |||
T62649 | HDAC-IN-34 | ||
HDAC-IN-34 (compound 27) is a potent inhibitor of HDAC that acts on HDAC1 (IC50: 0.022 μM) and HDAC6 (IC50: 0.45 μM). HDAC-IN-34 can bind to DNA and cause DNA damage. HDAC-IN-34 exhibits a significant anti-proliferative ... | |||
T36629 | Givinostat | ||
Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat (ITF2357) suppresses total LPS-induced IL-1β production robustly compared with the reduction by ITF30... |