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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T78212 | KRAS G12D inhibitor 18 | KRAS G12D IN 18 | Others |
KRAS G12D inhibitor 18 is a potent KRAS G12D inhibitor with potential anti-tumor and inhibitory activity against tumor cell proliferation for the study of pancreatic cancer. | |||
T78170 | Kras4B G12D-IN-1 | Ras | |
Kras4B G12D-IN-1 is an anticancer agent that functions as an inhibitor of the Kras4B G12D protein. It effectively reduces the expression of Kras protein in mouse embryonic fibroblasts (MEFs) harboring the Kras4B G12D mut... | |||
T9674 | KRAS G12D inhibitor 1 | ||
KRAS G12D inhibitor 1 (example 243) is an inhibitor of KRAS G12D with an IC 50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation [1]. | |||
T40282 | KRAS G12D inhibitor 7 | ||
KRAS G12D inhibitor 7, is a highly potent inhibitor specifically targeting KRAS G12D. | |||
T40281 | KRAS G12D inhibitor 6 | ||
KRAS G12D inhibitor 6 is an efficacious compound that effectively inhibits KRAS G12D. | |||
T40246 | KRAS G12D inhibitor 5 | ||
KRAS G12D inhibitor 5 is a KRAS G12D inhibitor for the potential treatment of pancreatic cancer. | |||
T77804 | KRAS G12D mutation regulator 4 | ||
T64178 | KRAS G12D inhibitor 13 | ||
KRAS G12D inhibitor 13 is a potent inhibitor of KRAS G12D. KRAS G12D inhibitor 13 has shown potential for the investigation of KRAS G12D-mediated cancers. | |||
T79072 | KRAS G12D modulator-1 | Ras | |
KRAS G12D modulator-1 (compound 6), a potent modulator of KRAS G12D, exhibits IC50 values ranging from 1-10 μM against NEA-G12D, PPI-G12D, and p ERK-AGS, and is utilized in cancer research [1]. | |||
T63028 | KRAS G12D inhibitor 12 | ||
KRAS G12D inhibitor 12 is an effective inhibitor of KRAS G12D. The Ras protein family is an important intracellular signaling molecule, which plays an important role in growth and development. KRAS G12D inhibitor 12 has ... | |||
T64031 | KRAS G12D inhibitor 9 | ||
KRAS G12D inhibitor 9 is a potent inhibitor of KRAS G12D. Among them, the RAS protein family is an important intracellular signaling molecule that plays an important role in growth and development. KRAS G12D inhibitor 9 ... | |||
T72345 | KRAS G12D inhibitor 10 | ||
KRAS G12D Inhibitor 10 is a potent agent targeting the KRAS G12D mutation, a variant in the Ras protein family crucial for cellular growth and development. This compound shows promise for investigating cancers mediated b... | |||
T74607 | KRAS G12D inhibitor 15 | ||
KRAS G12D inhibitor 15 is a potent inhibitor specifically targeting the KRAS G12D mutation. It holds potential for research into numerous diseases or disorders, including cancer and its metastases[1]. | |||
T72355 | KRAS G12D inhibitor 16 | ||
KRAS G12D Inhibitor 16 is a potent compound targeting the KRAS G12D and its mutation, exhibiting inhibitory activity with IC50 values of 0.7 nM and 0.35 μM, respectively. It is utilized in researching various malignant t... | |||
T62228 | KRAS G12D inhibitor 14 | Ras | |
KRAS G12D inhibitor 14 is a potent inhibitor of KRAS G12D that binds KRAS G12D protein (Kd: 33 nM). KRAS G12D inhibitor 14 inhibits the active form of KRAS G12D (KRAS G12D-GTP), but not KRAS G13D. | |||
T63577 | KRAS G12D inhibitor 11 | ||
KRAS G12D inhibitor 11 is a potent inhibitor of KRAS G12D. The Ras family of proteins are important intracellular signaling molecules that play an important role in growth and development, and KRAS G12D inhibitor 11 has ... | |||
T72394 | KRAS G12D inhibitor 3 | ||
KRAS G12D Inhibitor 3, a compound targeting the KRAS G12D mutation, demonstrates potent antitumor efficacy with an inhibitory concentration (IC50) of less than 500 nM. | |||
T74663 | KRAS G12D inhibitor 17 | ||
KRAS G12D Inhibitor 17 (example 8), a quinazoline-linked (4R)-4-hydroxy-L-prolinamide compound, acts as a proteolysis targeting chimera (PROTAC) [1], specifically inducing degradation of the G12D-mutation KRAS protein. | |||
T73828 | KRAS G12D inhibitor 3 TFA | ||
KRAS G12D Inhibitor 3 TFA, exhibiting an inhibitory concentration (IC50) of less than 500 nM, is effective as an antitumor agent. | |||
T9303 | MRTX1133 | Ras | |
MRTX1133 is a KRAS G12D inhibitor (KD=0.2 pM) that is potent, selective, and non-covalent. MRTX1133 exhibits inhibitory activity against KRAS G12D-mutated tumors, but not against KRAS wild-type tumors. |