fxi — TargetMol Chemicals

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Search Results for " fxi "

Compounds

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T39035	FXIa-IN-6
	FXIa-IN-6 is a potent FXIa inhibitor with selectivity against most of the relevant serine proteases ( K i = 0.3 nM). FXIa-IN-6 also demonstrated excellent pharmacokinetics (PK) profile (high oral bioavailability and low ...
T11341	FXIa-IN-1		Others
	FXIa-IN-1 is a potent β-lactam covalent heparin-derived factor XIa (fXIa) inhibitor.		Others
T64257	FXIa-IN-8
	FXIa-IN-8 is a potent and selective inhibitor of FXIa (IC50: 14.2 nM). FXIa-IN-8 exhibits anti-thrombotic effects and does not increase the risk of bleeding or significant toxicity sup>[1].
T62832	FXIa-IN-7
	FXIa-IN-7 is an orally active, selective factor Xia inhibitor (IC50: 0.4 nM).
T82361	FXIIa-IN-1
	XIIa-IN-1-IN-3 (Compound 22) is a Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 97.8 nM, utilized in the study of thrombosis [1].
T82360	FXIIa-IN-2
	XIIa-IN-1-IN-2 (Compound 21) serves as a potent Factor XIIa inhibitor with an apparent inhibition constant (K i app) of 62.2 nM, utilized primarily in thrombosis research [1].
T64098	FXIa-IN-10
	FXIa-IN-10 is a potent, orally bioavailable inhibitor of Activator XI (FXIa) (Ki: 0.17 nM).
T70458	FXIa-6f
	FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical species
T64099	FXIa-IN-9
	FXIa-IN-9 (compound 3f) is a potent, selective inhibitor of FXIa, demonstrating strong binding affinity through hydrogen bond formation (human FXIa K i : 0.17 nM, rabbit FXIa K i : 0.5 nM). It exhibits anticoagulant prop...
T77124	Osocimab	BAY 1213790	FXR
	Osocimab (BAY 1213790) is a potent anti-FXIa antibody with a Ki value of 2.4 nM and an EC50 value of 0.2 nM.Osocimab may reduce thrombosis through FXI inhibition.Osocimab is often used as an XI factor inhibitor, has an i...		FXR
T14682	BMS-962212		Others
	BMS-962212, a direct, reversible, and selective factor XIa (FXIa) inhibitor, demonstrates fast pharmacodynamic (PD) response onset and rapid elimination with a well-tolerated profile. It dependently increases activated p...		Others
T82044	ISIS 416858
	ISIS 416858, a potent and selective single-stranded antisense oligodeoxynucleotide, inhibits FXI mRNA expression effectively.
T76894	Abelacimab
	Abelacimab (MAA868), a fully human IgG1 monoclonal antibody, targets and binds with high affinity to FXI's catalytic structural domain. This interaction ensures FXI remains in its zymogen form, effectively inhibiting act...

Compounds

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-01104	Coagulation factor XI/F11 Protein, Human, Recombinant (His)	Human	HEK293 Cells
	Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the p...
TMPK-01271	Coagulation factor XI Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Factor XI (FXI) is the zymogen of a plasma protease (FXIa) that contributes to hemostasis by activating factor IX (FIX). In the original cascade model of coagulation, FXI is converted to FXIa by factor XIIa (FXIIa), a co...

Coagulation factor XI/F11 Protein, Human, Recombinant (His)

TMPY-01104

Species: Human

Expression System: HEK293 Cells

Coagulation factor XI Protein, Cynomolgus, Recombinant (His)

TMPK-01271

Species: Cynomolgus

Expression System: HEK293 Cells