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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9997 | GLL 398 | Estrogen Receptor/ERR | |
GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models. | |||
T25556 | JNJ-17148066 | JNJ 17148066,JNJ17148066 | |
JNJ-17148066 is an agonist of estrogen receptor ESR1. | |||
T73429 | VT02956 | ||
VT02956 is a LATS inhibitor ( IC 50 : 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organo... | |||
T78824 | ERD-3111 | Estrogen Receptor/ERR | |
ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft model harboring wild-type ER and two ESR1-mutated mouse model... | |||
T70399 | TTC-352 | ||
TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00762 | ER alpha Protein, Human, Recombinant (His) | Human | E. coli |
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a... | |||
TMPH-01305 | ER beta Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ... | |||
TMPH-01304 | ER beta Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ... | |||
TMPH-02221 | TRIM24 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the high... | |||
TMPY-02214 | OTUB1 Protein, Human, Recombinant (His) | Human | E. coli |
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla... |