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Search Results for " esr1 "

Targets

5

Compounds

5

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T9997 GLL 398 Estrogen Receptor/ERR
GLL 398 is an orally active and selective degrader of estrogen receptor with an IC50 of 1.14 nM. GLL 398 blocks tumor growth in xenograft breast cancer models.
T25556 JNJ-17148066 JNJ 17148066,JNJ17148066
JNJ-17148066 is an agonist of estrogen receptor ESR1.
T73429 VT02956
VT02956 is a LATS inhibitor ( IC 50 : 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organo...
T78824 ERD-3111 Estrogen Receptor/ERR
ERD-3111 (Compound 44), an orally active PROTAC ERα degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft model harboring wild-type ER and two ESR1-mutated mouse model...
T70399 TTC-352
TTC-352 is an orally bioavailable selective human estrogen receptor alpha (ERalpha; ESR1; ERa) partial agonist (ShERPA), with potential antineoplastic activity. Upon administration, TTC-352 mimics the naturally-occurring...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00762 ER alpha Protein, Human, Recombinant (His) Human E. coli
Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and a...
TMPH-01305 ER beta Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ...
TMPH-01304 ER beta Protein, Human, Recombinant (E. coli, His) Human E. coli
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ...
TMPH-02221 TRIM24 Protein, Human, Recombinant (His & SUMO) Human E. coli
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the high...
TMPY-02214 OTUB1 Protein, Human, Recombinant (His) Human E. coli
Ubiquitin thioesterase OTUB1, also known as Deubiquitinating enzyme OTUB1, OTU domain-containing ubiquitin aldehyde-binding protein 1, Otubain-1, Ubiquitin-specific-processing protease OTUB1, OTUB1 and OTB1, is a cytopla...
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