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Search Results for " eaat2 "

15

Compounds

Cat No. Product Name Synonyms Targets
T9347 EAAT2 activator 1 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine transporter
EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) is a thiopyridazine derivative that has been found to increase EAAT2 protein levels in astrocytes.
T15728 LDN-212320 LDN-0212320,LDN/OSU-0212320,OSU-0212320 transporter
LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h.
T15446 GT 949 transporter
GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).
T13330 WAY-213613 hydrochloride WAY-213613 hydrochloride (868359-05-1 free base) transporter
WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WA...
T13330L WAY-213613 transporter
WAY-213613 is a potent and selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 (IC50: 85 nM EAAT2). It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s: 5 and 3.8 μM, respectively). WAY-213613 shows ...
T11055 DL-TBOA transporter
DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner, with Ki values of 4.4 μM...
T22722 Dihydrokainic acid Others
EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake
T39510 DL-TBOA ammonium
DL-TBOA ammonium is a potent, non-transportable inhibitor of excitatory amino acid transporters. Its inhibitory effects are demonstrated by IC50 values of 70 μM, 6 μM, and 6 μM for excitatory amino acid transporter-1 (EA...
T23454 TFB-TBOA Others
glial glutamate transporter EAAT1 and EAAT2 inhibitor
T69528 GTS467
GTS467 is a EAAT2 Activator.
T69227 GT951
GT951 is a EAAT2 activator.
T29153 WAY-855
WAY-855 is an EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake.
T60768 SN05
SN05 is a potent inhibitor of amino acid transport (AAT) that can be used in anticancer research. The Ki values of SN05 for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5 is 2.77 μM, 0.73 μM, 0.87 μM,...
T68345 GTS511
GTS511 is a EAAT2 Activator. Pharmacokinetic profiles (PK) of GTS511 show a >6 h half-life and higher bioavailability in plasma and the brain under all three routes of administration in rats. GTS511 can be further develo...
T60642 SN40
SN40 is a potent amino acid transport (AAT) inhibitor that can be used in anticancer research. SN40 has Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT...
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