15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9347 | EAAT2 activator 1 | 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine | transporter |
EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) is a thiopyridazine derivative that has been found to increase EAAT2 protein levels in astrocytes. | |||
T15728 | LDN-212320 | LDN-0212320,LDN/OSU-0212320,OSU-0212320 | transporter |
LDN-212320 (OSU-0212320) is a glutamate transporter EAAT2 activator. It also enhances EAAT2 levels by > 6 fold at concentrations < 5 μM after 24 h. | |||
T15446 | GT 949 | transporter | |
GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM). | |||
T13330 | WAY-213613 hydrochloride | WAY-213613 hydrochloride (868359-05-1 free base) | transporter |
WAY-213613 hydrochloride is a potent, selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 with IC 50 of 85 nM. WAY-213613 hydrochloride inhibits EAAT1 and EAAT3 with IC50 values of 5 and 3.8 microM, respectively. WA... | |||
T13330L | WAY-213613 | transporter | |
WAY-213613 is a potent and selective nonsubstrate reuptake inhibitor of GLT-1/EAAT2 (IC50: 85 nM EAAT2). It displays 59- and 44-fold selectivity over EAAT1 and EAAT3 (IC50s: 5 and 3.8 μM, respectively). WAY-213613 shows ... | |||
T11055 | DL-TBOA | transporter | |
DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner, with Ki values of 4.4 μM... | |||
T22722 | Dihydrokainic acid | Others | |
EAAT2(GLT1)-selective non-transportable inhibitor of L-glutamate and L-aspartate uptake | |||
T39510 | DL-TBOA ammonium | ||
DL-TBOA ammonium is a potent, non-transportable inhibitor of excitatory amino acid transporters. Its inhibitory effects are demonstrated by IC50 values of 70 μM, 6 μM, and 6 μM for excitatory amino acid transporter-1 (EA... | |||
T23454 | TFB-TBOA | Others | |
glial glutamate transporter EAAT1 and EAAT2 inhibitor | |||
T69528 | GTS467 | ||
GTS467 is a EAAT2 Activator. | |||
T69227 | GT951 | ||
GT951 is a EAAT2 activator. | |||
T29153 | WAY-855 | ||
WAY-855 is an EAAT2-preferring, nonsubstrate inhibitor of high-affinity glutamate uptake. | |||
T60768 | SN05 | ||
SN05 is a potent inhibitor of amino acid transport (AAT) that can be used in anticancer research. The Ki values of SN05 for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5 is 2.77 μM, 0.73 μM, 0.87 μM,... | |||
T68345 | GTS511 | ||
GTS511 is a EAAT2 Activator. Pharmacokinetic profiles (PK) of GTS511 show a >6 h half-life and higher bioavailability in plasma and the brain under all three routes of administration in rats. GTS511 can be further develo... | |||
T60642 | SN40 | ||
SN40 is a potent amino acid transport (AAT) inhibitor that can be used in anticancer research. SN40 has Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT... |