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GT 949

Catalog No. T15446 CAS 460330-27-2

GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).

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GT 949, CAS 460330-27-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 64.00
10 mg	In stock	$ 113.00
25 mg	In stock	$ 228.00
50 mg	In stock	$ 413.00
100 mg	In stock	$ 618.00
500 mg	In stock	$ 1,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 74.00

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Purity: 99.89%

Biological Description

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Description	GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).
Targets&IC50	EAAT2:(EC50)0.26±0.03 nM
In vitro	GT 949 displays selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3. GT 949 improves glutamate transport (EC50 = 0.26 nM) and increases glutamate transport in a non-competitive manner with an increase in Vmax of about 47% in EAAT2-transfected cells[1].

Molecular Weight	527.66
Formula	C30H37N7O2
CAS No.	460330-27-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (85.3 mM), Sonication is recommended.

References and Literature

1. Kortagere S, et al. Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2. ACS Chem Neurosci. 2018 Mar 21;9(3):522-534.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GT 949 460330-27-2 Metabolism transporter GT949 GT-949 inhibitor inhibit

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