Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner, with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA is an effective non-transportable excitatory amino acid transporter inhibitor with IC50 of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter 1 (EAAT1, EAAT2 and EAAT3), respectively.
Description | DL-TBOA inhibited [14C] glutamate uptake in COS-1 cells expressing human EAAT1 and EAAT2, with Ki values of 42 μM and 5.7 μM, respectively. DL-TBOA blocks EAAT4 and EAAT5 in a competitive manner, with Ki values of 4.4 μM and 3.2 μM, respectively. DL-TBOA is an effective non-transportable excitatory amino acid transporter inhibitor with IC50 of 70 μM, 6 μM and 6 μM for excitatory amino acid transporter 1 (EAAT1, EAAT2 and EAAT3), respectively. |
Targets&IC50 | EAAT2:6 μM , EAAT3:6 μM , EAAT5:3.2 μM , EAAT1:70 μM , EAAT4:4.4 μM , EAAT1 (human):(ki)42 μM , EAAT2 (human):5.7 μM |
In vitro | DL-TBOA reversed the loss of viability caused by oxaliplatin. DL-TBOA (350 μM; 24 hours; HCT116 and LoVo cell lines) treatment can reduce the induction of p53 by SN38 and oxaliplatin. DL-TBOA (70-350 μM; 48 hours; HCT116 and LoVo cell lines) treatment concentration-dependently enhanced SN38-induced loss of vitality. |
Molecular Weight | 239.22 |
Formula | C11H13NO5 |
CAS No. | 205309-81-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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DL-TBOA 205309-81-5 Metabolism transporter DLTBOA DL TBOA inhibitor inhibit