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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T60824 | Dyrk1A-IN-3 | ||
Dyrk1A-IN-3 (Compound 8b) is a highly selective inhibitor of dual-specificity tyrosine-regulated kinase 1A (DYRK1A). Dyrk1A-IN-3 has high binding affinity of DYRK1A with an IC 50 of 76 nM. Dyrk1A-IN-3 can be used in neur... | |||
T14980 | CLK-IN-T3 | DYRK , CDK | |
CLK-IN-T3 is an inhibitor of CLK1, CLK2, and CLK3 with IC50s of 0.67, 15, and 110 nM. CLK-IN-T3 exhibits anti-cancer activity. | |||
T72039 | CLK1-IN-3 | DYRK , CDK , Autophagy | |
Clk1-in-3 is a + selective and highly potent sexual Clk1 inhibitor with an IC50 of 5 nM and 300 pairs higher affinity than Dyrk1A. CLK1-IN-3 also showed highly effective inhibition of Clk2 and Clk4, with IC50 values of 4... | |||
T62790 | JH-XIV-68-3 | ||
JH-XIV-68-3 is a selective inhibitor of the DYRK1A/B macrocycle.JH-XIV-68-3 selectively acts on DYRK1A and its close relative DYRK1B in biochemical and cellular assays.JH-XIV-68-3 has antitumor effects in head and neck s... | |||
T63050 | JH-XVII-10 | ||
JH-XVII-10 is a selective, orally active and potent inhibitor of DYRK1A (IC50: 3 nM) and DYRK1B (IC50: 5 nM).JH-XVII-10 exhibits antitumor effects in squamous cell carcinoma of the neck (HNSCC) cell lines. | |||
T74805 | T74805 | ||
CLK1-IN-3 (compound 10ad) is a potent and selective Clk1 inhibitor, with an IC 50 of 5 nM and over 300-fold selectivity for Dyrk1A . CLK1-IN-3 also shows a relatively potent inhibition against Clk2 and Clk4 , with IC 50 ... |