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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4198 | T.cruzi-IN-1 | MDK1088,T.cruzi Inhibitor | Antibiotic , Parasite |
T.cruzi-IN-1 (MDK1088) is a Trypanosoma cruzi inhibitor. | |||
T7725 | Albaconazole | W 0027,UR-9825,UR9825,W-0027 | P450 , Antifungal |
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, skin and musculoskeletal disorders, and can be used in the s... | |||
T25156 | BiPNQ | ||
BiPNQ is a Trypanosoma cruzi inhibitor. Trypanosoma cruzi is the etiological agent of Chagas disease (American trypanosomiasis). | |||
T31215 | DB-766 | DB766 | |
DB-766 is a potential chemotherapeutic candidate for Chagas' disease treatment. DB-766 exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y stra... | |||
T28011 | Megazol | CL 64855,CL-64855,CL64855 | |
Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping si... | |||
T71487 | WRR-483 | ||
WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency ag... | |||
T62362 | GNF6702 | ||
GNF6702 is a selective inhibitor of the kinetoplastid proteasome and has been shown to be effective against parasites in mouse models of leishmaniasis, Chagas disease and human African trypanosomiasis. | |||
T79316 | Antitrypanosomal agent 15 | Proteasome | |
Antitrypanosomal Agent 15 (Compound 26) is an orally active, brain-penetrant, selective inhibitor of the Trypanosoma cruzi proteasome, exhibiting a pIC50 of 7.4 for T. cruzi and <4 for the human proteasome. It possesses ... | |||
T75118 | AN15368 | ||
AN15368, an orally administered small-molecule precursor, undergoes activation by parasite carboxypeptidase, yielding a product that interferes with the messenger RNA processing pathway in T. cruzi. This compound shows p... | |||
T79539 | Topoisomerase II inhibitor 16 | Topoisomerase | |
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D... | |||
T73068 | Mammea A/BA | ||
Mammea A/BA demonstrates significant efficacy in inhibiting Trypanosoma cruzi (T. cruzi), through mechanisms such as mitochondrial dysfunction, increased production of reactive oxygen species (ROS), and DNA fragmentation... |