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Search Results for " chagas "

11

Compounds

Cat No. Product Name Synonyms Targets
T4198 T.cruzi-IN-1 MDK1088,T.cruzi Inhibitor Antibiotic , Parasite
T.cruzi-IN-1 (MDK1088) is a Trypanosoma cruzi inhibitor.
T7725 Albaconazole W 0027,UR-9825,UR9825,W-0027 P450 , Antifungal
Albaconazole (W-0027) is a small molecule fungal cytochrome P450 family member 51 (fungal CYP51A1) inhibitor. It is used in the treatment of fungal infections, skin and musculoskeletal disorders, and can be used in the s...
T25156 BiPNQ
BiPNQ is a Trypanosoma cruzi inhibitor. Trypanosoma cruzi is the etiological agent of Chagas disease (American trypanosomiasis).
T31215 DB-766 DB766
DB-766 is a potential chemotherapeutic candidate for Chagas' disease treatment. DB-766 exhibits strong trypanocidal activity and excellent selectivity for bloodstream trypomastigotes and intracellular amastigotes (Y stra...
T28011 Megazol CL 64855,CL-64855,CL64855
Megazol is a nitroimidazole based drug that cures some protozoan infections. A study of nitroimidazoles found the drug extremely effective against T. cruzi and T. brucei which cause Chagas disease and African sleeping si...
T71487 WRR-483
WRR-483, an analogue of K-11777, is a potent and selective cysteine protease inhibitor with trypanocidal activity in cell culture and animal model with comparable efficacy to K11777. WRR-483 demonstrates good potency ag...
T62362 GNF6702
GNF6702 is a selective inhibitor of the kinetoplastid proteasome and has been shown to be effective against parasites in mouse models of leishmaniasis, Chagas disease and human African trypanosomiasis.
T79316 Antitrypanosomal agent 15 Proteasome
Antitrypanosomal Agent 15 (Compound 26) is an orally active, brain-penetrant, selective inhibitor of the Trypanosoma cruzi proteasome, exhibiting a pIC50 of 7.4 for T. cruzi and <4 for the human proteasome. It possesses ...
T75118 AN15368
AN15368, an orally administered small-molecule precursor, undergoes activation by parasite carboxypeptidase, yielding a product that interferes with the messenger RNA processing pathway in T. cruzi. This compound shows p...
T79539 Topoisomerase II inhibitor 16 Topoisomerase
Topoisomerase II Inhibitor 16 (compound CT3) is a selective, orally bioavailable, and irreversible inhibitor of trypanosomal topoisomerase II, possessing the ability to penetrate the brain and stabilize double-stranded D...
T73068 Mammea A/BA
Mammea A/BA demonstrates significant efficacy in inhibiting Trypanosoma cruzi (T. cruzi), through mechanisms such as mitochondrial dysfunction, increased production of reactive oxygen species (ROS), and DNA fragmentation...
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