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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T36236 | 5-cis Carbaprostacyclin | ||
5-cis Carbaprostacyclin is a stable analog of PGI2 and an isomer of carbaprostacyclin. It is a weak inhibitor of human platelet aggregation with an IC50 of 2.8 μM compared to 0.3 μM for carbaprostacyclin. 5-cis Carbapros... | |||
T36774 | 13,14-dehydro-15-cyclohexyl Carbaprostacyclin | ||
13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2. It inhibits the ADP-induced aggregation of human platelets with an ED50 of about 40 nM in PRP and 77 nM in washed platelets, which is c... | |||
T10673 | Carbacyclin | Carbaprostacyclin,Carba-PGI2 | Others |
Carbacyclin, a PGI2 analog, is a prostacyclin (PGI2) receptor agonist and vasodilator with potent inhibitory platelet aggregation. | |||
T4436 | RO1138452 | CAY10441 | Others , Prostaglandin Receptor |
RO1138452 (CAY10441) is a selective and orally bioavailable antagonist of prostacyclin receptor (pKi: 8.3). It antagonizes the carbaprostacyclin-induced activation of human neuroblastoma adenylate cyclase, blocking cycli... | |||
T36732 | Ciprostene (calcium salt) | ||
Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension a... | |||
T36212 | 16(S)-Iloprost | ||
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to ... | |||
T36211 | 16(R)-Iloprost | ||
Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin. Iloprost binds with equal affinity to ... |