cyp51 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T64154	CYP51/HDAC-IN-1
	CYP51/HDAC-IN-1 is an orally active, potent, dual CYP51/HDAC inhibitor that inhibits important virulence factors and down-regulates the expression of associated drug resistance genes.CYP51/HDAC-IN-1 has shown effective t...
T78902	CYP51/PD-L1-IN-4
	CYP51/PD-L1-IN-4 (compound 14a-2) is a potent dual-target inhibitor of CYP51/PD-L1, displaying IC50 values of 0.17 and 0.021 μM, respectively. This compound demonstrates significant antifungal efficacy and combats drug-r...
T79740	CYP51/PD-L1-IN-3
	CYP51/PD-L1-IN-3 (compound L21), a quinazoline with antifungal properties, serves as a dual inhibitor targeting CYP51 (IC50: 0.205 μM) and PD-L1 (IC50: 0.039 μM). This compound promotes early fungal apoptosis within the ...
T79738	CYP51/PD-L1-IN-1
	CYP51/PD-L1-IN-1 (compound L11), a quinazoline with antifungal properties, simultaneously inhibits CYP51 (IC50: 0.884 μM) and PD-L1 (IC50: 0.083 μM). This compound prompts early apoptosis in the fungal cell cycle, marked...
T79739	CYP51/PD-L1-IN-2
	CYP51/PD-L1-IN-2 (compound L20), a quinazoline with antifungal properties, is a potent dual inhibitor targeting both CYP51 (IC50: 0.263 μM) and PD-L1 (IC50: 0.017 μM). The compound promotes early apoptosis in the fungal ...
T4188	SDZ285428	SDZ285-428	P450 , Parasite , Antifungal
	SDZ285428 is a CYP24A1 inhibitor.		P450 , Parasite , Antifungal
T17022	Tebuconazole		P450 , Antifungal
	Tebuconazole is an agricultural azole fungicide. It can also inhibit CYP51 (IC50s: 0.9 and 1.3 μM for Candida albicans CYP51 and truncated Homo sapiens CYP51, respectively).		P450 , Antifungal
T16412	Oteseconazole	VT-1161	P450 , Antifungal
	Oteseconazole (VT-1161) is an orally active anti-fungal agent. Oteseconazole displays no obvious effect on human CYP51. It also potently binds to and inhibits Candida albicans CYP51 (Kd, <39 nM).		P450 , Antifungal
T16704L	Quilseconazole Formic acid(1340593-70-5 Free base)	Quilseconazole Formic acid(1340593-70-5 Free base)	Antifungal
	Quilseconazole Formic acid is a selective inhibitor of fungal Cyp51 with potent activities against Cryptococcus neoformans and Cryptococcus gattii.		Antifungal
T11991	Mefentrifluconazole		P450 , Antifungal
	Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). Mefentrifluconazole is a novel azole derivative and ...		P450 , Antifungal
T3934	Isavuconazonium sulfate		Antifungal
	Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), wh...		Antifungal
TN6736	Dihydrolanosterol	24,25-Dihydrolanosterol,Lanostenol	Others
	Dihydrolanosterol (24,25-Dihydrolanosterol) is a sterol and the C24-25 hydrogenated products of lanosterol, dihydrolanosterol can be demethylated by mammal or yeast cytochrome P450 sterol 14alpha-demethylase		Others
T16704	Quilseconazole	VT-1129	Others
	Quilseconazole is an effective, orally active fungal Cyp51 inhibitor. it also binds tightly to cryptococcal CYP51 but weakly inhibits humans CYP450 enzymes.		Others
T12286	Obtusifoliol		Others
	Obtusifoliol is a specific inhibitor of CYP51(Trypanosoma brucei (TB) and human CYP51 with Kd values of 1.2 µM and 1.4 µM, respectively).		Others
T63285	Antifungal agent 40
	Antifungal agent 40 is an antifungal agent that extends into the narrow hydrophobic pocket II of C. alb. CYP51 and inhibits the activity of lanosterol 14α-demethylase (CYP51), which has an inhibitory effect on biofilm fo...
T72660	VT-1598 tosylate
	VT-1598 tosylate is a selective, orally active antifungal compound that targets CYP51. It demonstrates efficacy against C. auris.
T27851	LP8	LP 8,LP-8
	LP8 is a novel inhibitor of Trypanosoma cruzi CYP51.
T28739	SDZ-285604	SDZ285604,VNF,SDZ 285604
	SDZ-285604 is a novel sterol 14a-demethylases (CYP51) inhibitor.
T70158	Quilseconazole besylate
	Quilseconazole besylate, also known as VT-1129 besylate, is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor.
T79550	Antifungal agent 68
	Antifungal agent 68 (compound 10) effectively combats fungal infections caused by Candida and Cryptococcus gattii through the inhibition of ergosterol biosynthesis, likely via interaction with lanosterol 14α-demethylase ...