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Cat No. | Product Name | Synonyms | Targets |
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T14834 | BT2 | BCL | |
BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, l... | |||
T79755 | PF-07208254 | Endogenous Metabolite | |
PF-07208254, a potent BDK inhibitor, enhances cardiometabolic endpoints in mice [1]. | |||
T79358 | PF-07247685 | Endogenous Metabolite | |
PF-07247685, a potent BCKDC kinase (BDK) inhibitor (EC 50 = 2.2 nM), enhances the binding between BDK and the BCKDH E2 core subunit to block E1 phosphorylation. BDK regulation is crucial for BCKDH activity, which manages... | |||
T79357 | PF-07238025 | Endogenous Metabolite | |
PF-07238025, a potent branched-chain ketoacid dehydrogenase kinase (BDK) inhibitor with an EC50 of 19 nM, enhances the stability of the BDK-BCKDH core E2 subunit interaction and inhibits the phosphorylation of the E1 sub... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01598 | Kininogen 1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Kininogen 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.3 kDa and the accession number is P01042-1. | |||
TMPJ-00734 | KNG1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Kininogen-1 is a secreted protein which contains three cystatin domains. There are two alternatively spliced forms, designated as the high molecular weight (HMW) and low MW (LMW) forms. Kininogen-1 plays a critical role ... |