abl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TP1483L	Abl Cytosolic Substrate acetate	Abl Cytosolic Substrate acetate(168202-46-8 free base)	Others
	Abl Cytosolic Substrate acetate is a substrate for Abelson tyrosine kinase (Abl ).		Others
T10800	CHMFL-ABL-121		Bcr-Abl
	CHMFL-ABL-121 is a highly potent inhibitor of type II ABL kinase (IC50s: 2 nM and 0.2 nM against purified inactive ABL wt and T315I kinase protein).		Bcr-Abl
T10799	CHMFL-ABL-039		Bcr-Abl
	CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor (IC50s: 7.9 nM and 27.9 nM) used in the research of chronic myeloid leukemia.		Bcr-Abl
T72958	BCR-ABL-IN-7		Bcr-Abl
	BCR-ABL-IN-7 is a WT and T315I mutant ABL kinase inhibitor.BCR-ABL-IN-7 potently inhibits WT and T315I mutant ABL kinase activity.BCR-ABL-IN-7 can be used in chronic myelogenous leukemia (CML) research.		Bcr-Abl
T10801	CHMFL-ABL/KIT-155	CHMFL-ABL-KIT-155	c-Kit
	CHMFL-ABL/KIT-155 is a highly potent and orally active type II ABL/c-KIT dual kinase inhibitor (IC50s: 46 nM/75 nM). It arrests cell cycle progression and induces apoptosis.		c-Kit
T18595	Dasatinib carbaldehyde	PROTAC ABL binding moiety 4,BMS-354825 carbaldehyde	Others , Ligands for Target Protein for PROTAC
	Dasatinib carbaldehyde (PROTAC ABL binding moiety 4) is based on Dasatinib which is an ABL inhibitor, binds to the IAP ligand via a linker, and forms SNIPER [1].		Others , Ligands for Target Protein for PROTAC
T18690	SNIPER(ABL)-039		Others
	SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, c...		Others
T18685	SNIPER(ABL)-015		Others
	SNIPER(ABL)-015, a compound that conjugates GNF5 (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 5 μM [1].		Others
T18686	SNIPER(ABL)-019		Others
	SNIPER(ABL)-019, a compound that links Dasatinib (ABL inhibitor) to MV-1 (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, exhibiting a DC50 of 0.3 μM[1].		Others
T39732	BCR-ABL-IN-3
	BCR-ABL-IN-3 is a highly effective and irreversibly binding inhibitor of Bcr-Abl, displaying a remarkable potency with an IC50 value of ≤100 nM for Ba/F3 Bcr-Abl T3151. This compound exhibits significant anti-cancer acti...
T39827	C-ABL-IN-1
	C-ABL-IN-1 is a new and specific inhibitor of the c-Abl protein, which effectively prevents the progression of neurodegeneration observed in Parkinson's disease.
T18684	SNIPER(ABL)-013		Others
	SNIPER(ABL)-013, a compound that links GNF5 (ABL inhibitor) with Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels with a DC50 of 20 μM[1].		Others
T18693	SNIPER(ABL)-049		Others
	SNIPER(ABL)-049, a compound that conjugates Imatinib (ABL inhibitor) with Bestatin (IAP ligand) through a linker, effectively reduces BCR-ABL protein levels, demonstrating a DC50 of 100 μM[1].		Others
T18687	SNIPER(ABL)-020		Others
	SNIPER(ABL)-020 is a chemical compound consisting of Dasatinib, an ABL inhibitor, and Bestatin, an IAP ligand, conjugated with a linker. This compound effectively reduces the BCR-ABL protein[1].		Others
T18691	SNIPER(ABL)-044		Others
	SNIPER(ABL)-044, a compound that links HG-7-85-01 (ABL inhibitor) to Bestatin (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a DC50 value of 10 μM[1].		Others
T18688	SNIPER(ABL)-024		Others
	SNIPER(ABL)-024, a compound that conjugates GNF5 (ABL inhibitor) to an LCL161 derivative (IAP ligand) via a linker, effectively reduces BCR-ABL protein levels, achieving a half-maximal degradation concentration (DC50) of...		Others
T18695	SNIPER(ABL)-058		Others
	SNIPER(ABL)-058, a compound that links Imatinib (ABL inhibitor) with a derivative of LCL161 (IAP ligand) through a linker, effectively decreases BCR-ABL protein levels, achieving a half-maximal degradation concentration ...		Others
T18692	SNIPER(ABL)-047		Others
	SNIPER(ABL)-047, a compound that links HG-7-85-01 (an ABL inhibitor) to MV-1 (an IAP ligand) via a linker, effectively decreases the BCR-ABL protein levels, achieving a DC50 value of 2 μM[1].		Others
T34670	SNIPER(ABL)-38
	SNIPER(ABL)-38 is a specific and nongenetic IAP-dependent protein eraser (SNIPER) which acts as a protein degradation inducer of oncogenic BCR-ABL protein.
T18694	SNIPER(ABL)-050		Others
	SNIPER(ABL)-050 is a chemical compound that combines Imatinib, an ABL inhibitor, with MV-1, an IAP ligand, using a linker. This conjugation results in the reduction of BCR-ABL protein[1].		Others