Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1].
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Description | SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 of 10 nM. IC50s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively[1]. |
Targets&IC50 | cIAP2:12 nM (IC50), XIAP:50 nM (IC50), Abl:0.54 nM (IC50), Abl:10 nM (DC50), cIAP1:10 nM (IC50) |
Molecular Weight | 1114.77 |
Formula | C54H68ClN11O9S2 |
CAS No. | 2222354-29-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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SNIPER(ABL)-039 2222354-29-0 Others SNIPER(ABL)039 SNIPER(ABL) 039 inhibitor inhibit