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Search Results for " atx-ii "

Targets

3

Compounds

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T80039 ATX-II Sodium Channel
ATX-II, an Na+ channel modulator toxin derived from the sea anemone (Anemonia sulcata), causes delayed inactivation of the Na+ channels and has been linked to pulmonary vein arrhythmogenesis and atrial fibrillation [1] [...
T82936 ATX-II TFA Sodium Channel
ATX-II TFA, a specific Na+ channel modulator toxin, is derived from the venom of the sea anemone (Anemonia sulcata). This compound impedes the inactivation of Na+ channels and has been associated with arrhythmogenesis in...
T69652 Relutrigine PRAX-562
Relutrigine (PRAX-562), an orally active persistent sodium channel inhibitor, potently and selectively targets persistent I Na, induced either by ATX-II (Nav 1.5 activator) or SCN8A mutation N1768D, with IC 50 values of ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-00056 Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) Anemonia sulcata P. pastoris (Yeast)
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent...
TargetMol