3clpro — TargetMol Chemicals

Cat No.	Product Name	Targets
T77652	SARS-CoV-2 3CLpro-IN-20	Antiviral , SARS-CoV
	SARS-CoV-2 3CLpro-IN-20 is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.43 μM,).SARS-CoV-2 3CLpro-IN-20 has potential antiviral activity.	Antiviral , SARS-CoV
T79659	SARS-CoV-2 3CLpro-IN-16	SARS-CoV
	SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.	SARS-CoV
T61774	SARS 3CLpro-IN-1
	SARS 3CLpro-IN-1 (Compound 3b) is a stereo-specific SARS 3CL protease inhibitor that belongs to the octahydroisochromene scaffold. It demonstrates inhibition against the P1 site imidazole, with an IC50 value of 95 μM [1]...
T9351	Nirmatrelvir	SARS-CoV
	PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .	SARS-CoV
T79660	SARS-CoV-2 3CLpro-IN-17	SARS-CoV
	Compound 3h, also known as SARS-CoV-2 3CLpro-IN-17, is a selective inhibitor of the SARS-CoV-2 3CL protease, demonstrating an IC50 of 0.322 μM [1].	SARS-CoV
T63385	SARS-CoV-2 3CLpro-IN-2
	SARS-CoV-2 3CLpro-IN-2 is a potent inhibitor of the 3CL protease pair and has shown research potential for SARS-CoV-2 disease.
T79376	SARS-CoV-2 3CLpro-IN-19	SARS-CoV
	SARS-CoV-2 3CLpro-IN-19 (Compound C5a), a non-covalent, non-peptide inhibitor of the SARS-CoV-2 3CLpro enzyme, exhibits potent in vitro activity with an IC50 of 0.7 μM. It demonstrates broad-spectrum efficacy against inf...	SARS-CoV
T72370	SARS-CoV-2 3CLpro-IN-6
	SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor targeting the SARS-CoV-2 3CL protease, demonstrating potent inhibitory activity with an IC50 of 4.9 μM. It is utilized in the research of coronavirus disease 2019...
T79661	SARS-CoV-2 3CLpro-IN-18	SARS-CoV
	SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent inhibitor of SARS-CoV-2 3CLpro with an IC50 of 0.478 μM. It demonstrates inhibition of SARS-CoV-2 in Vero E6 cells, with an EC50 of 2.499 μM, and exhibits low cytotoxic...	SARS-CoV
T79676	SARS-CoV-2 3CLpro-IN-21	Virus Protease
	SARS-CoV-2 3CLpro-IN-21 (Compound D6) is an irreversible, covalent inhibitor of SARS-CoV-2 3CL pro, demonstrating potent inhibition with an IC50 of 0.03 μM. Additionally, it exhibits inhibitory activity against SARS-CoV-...	Virus Protease
T72313	SARS-CoV-2 3CLpro-IN-11
	SARS-CoV-2 3CLpro-IN-11(11d) is a broad-spectrum antiviral compound that effectively inhibits the SARS-CoV-2 3CL protease, achieving an IC50 of 140 nM. Additionally, it exhibits inhibitory activity against SARS-CoV-1 and...
T62734	SARS-CoV-2 3CLpro-IN-4
	SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a multifunctional inhibitor of SARS CoV-2 3CLpro, exhibiting antiviral, antibacterial, and antifungal activities.
T63679	SARS-CoV-2 3CLpro-IN-3
	SARS-CoV-2 3CLpro-IN-3 is a SARS CoV-2 3CLpro inhibitor that exhibits antiviral, antibacterial, and antifungal effects.
T72364	SARS-CoV-2 3CLpro-IN-5	SARS-CoV
	SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor targeting the 3C-like protease (3CLpro), exhibiting potent inhibitory activity with an IC50 of 3.8 nM and demonstrating 9.0% oral bioavailability (BA). It is utilized in the...	SARS-CoV
T79462	SARS-CoV-2 3CLpro-IN-14	SARS-CoV
	SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active inhibitor of SARS-CoV-2 3CLpro, demonstrating potent anti-SARS-CoV-2 properties with an EC50 of 0.18 μM and exhibits minimal cytotoxicity, having a CC50 greater ...	SARS-CoV
T80657	SARS-CoV-2 3CLpro-IN-15	Virus Protease
	SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral replication and transcription. It is instrumental in the id...	Virus Protease
T72371	SARS-CoV-2 3CLpro-IN-7
	SARS-CoV-2 3CLpro-IN-7 is a reversible covalent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an inhibitory concentration (IC50) value of 1.4 µM.
T63537	SARS-CoV-2 3CLpro-IN-1
	SARS-CoV-2 3CLpro-IN-1 (Compound 14c) is a highly potent inhibitor specifically designed to target and inhibit the activity of SARS-CoV-2 3CL pro, which is a cysteine-protease found in the main coronaviruses. This partic...
T74807	SARS-CoV-2 3CLpro-IN-13
	SARS-CoV-2 3CLpro-IN-13 is a potent inhibitor of the SARS-CoV-2 3CL protease, demonstrating significant anti-coronavirus activity with an IC50 value of 21 nM [1].
T72312	SARS-CoV-2 3CLpro-IN-10
	SARS-CoV-2 3CLpro-IN-10(5d) is a potent inhibitor of the SARS-CoV-2 3CL protease, exhibiting an IC50 value of 190 nM, and demonstrates varied efficiency against other coronaviruses with IC50 values of 790 nM for SARS-CoV...