Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 5 days | $ 814.00 | |
500 μg | 5 days | $ 3,250.00 | |
1 mg | 5 days | $ 5,440.00 |
Description | Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. |
Species | Mouse |
Expression System | HEK293 |
Tag | C-His |
Accession Number | A7E1W8-1 |
Synonyms | CD33 molecule-like 3, Siglec15, CD33L3, HsT1361, CD33 antigen-like 3, SIGLEC-15 |
Construction | Recombinant Biotinylated Mouse Siglec-15/CD33L3 Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the C-Terminus. It contains Arg24-Thr262.[Accession |A7E1W8-1] |
Protein Purity | > 95% as determined by Tris-Bis PAGE |
Molecular Weight | The protein has a predicted MW of 26.7 kDa. Due to glycosylation, the protein migrates to 35-43 kDa based on Tris-Bis PAGE result. |
Endotoxin | Less than 1EU per μg by the LAL method. |
Formulation | Supplied as 0.22μm filtered solution in 20mM PB, 0.5M NaCl, 0.1M L-arginine (pH 7.4). |
Stability & Storage |
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Shipping |
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. |
Research Background | Siglec-15 is a transmembrane glycoprotein in the Siglec family of sialic acid-binding immune regulatory molecules. Mature human Siglec-15 consists of a 244 amino acid extracellular domain (ECD) with two Ig-like domains, a 21 aa transmembrane segment, and a 44 aa cytoplasmic domain. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates. |
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Siglec-15 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated CD33 molecule-like 3 HsT-1361 Siglec15 SIGLEC15 HsT 1361 CD33L3 HsT1361 CD33 antigen-like 3 SIGLEC 15 SIGLEC-15 recombinant recombinant-proteins proteins protein