Claudin-18.2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-6xHis and C-Avi tag. The predicted molecular weight is 13 KDa and the accession number is P56856-2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 μg | 5 days | $ 534.00 | |
100 μg | 5 days | $ 1,450.00 |
Description | Claudin-18.2 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in E. coli expression system with N-6xHis and C-Avi tag. The predicted molecular weight is 13 KDa and the accession number is P56856-2. |
Species | Human |
Expression System | E. coli |
Tag | N-6His,C-Avi |
Accession Number | P56856-2 |
Synonyms | Claudin-18, CLDN18 |
Amino Acid | extracellular |
Construction | Biotinylated Recombinant Human CLDN18.2 is produced by our E.coli expression system and the target gene encoding extracellular is expressed with a 6His tag at the N-terminus. |
Molecular Weight | 13 KDa, reducing conditions |
Endotoxin | Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
Formulation | Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8M Urea, 150mM NaCl, 5mM β-ME, pH 8.5. |
Stability & Storage |
Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles. |
Shipping |
The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Claudin-18(CLDN18) is a protein that in humans is encoded by the CLDN18 gene. It belongs to the group of claudins. CLDN18 belongs to the large claudin family of proteins, which form tight junction strands in epithelial cells. CLDN18 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. CLDN18 has two isoform A1 and isoform A2. IMAB362 (Claudiximab) is a monoclonal antibody against isoform 2 of Claudin-18. It is under investigation for the treatment of gastrointestinal adenocarcinomas and pancreatic tumors. IMAB362 was developed by Ganymed Pharmaceuticals AG. |
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Claudin-18.2 Protein, Human, Recombinant (His & Avi), Biotinylated CLDN 18 CLDN-18 Claudin-18 CLDN18 recombinant recombinant-proteins proteins protein