Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes. Examination of the different signaling cascades induced by RTKs established Ras/MAPK, PI3K, and phospholipase-γ (PLCγ) pathways as key downstream mediators of PDGFR signaling. In addition, reactive oxygen species (ROS)-dependent STAT3 activation has been established to be a key downstream mediator of PDGFR signaling in vascular smooth muscle cells.
Cat No. | product name / Synonyms | Species | Expression System |
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TMPK-00419 | PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi)
PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. Th... | |||
TMPK-00420 | PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
PDGF R alpha/PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. Th... | |||
TMPK-00421 | PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi)
PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi)
|
Human | HEK293 Cells |
PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 59 kDa an... | |||
TMPK-00422 | PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated
PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
PDGF R beta/CD140b Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weigh... | |||
TMPK-00481 | PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)
PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 Cells |
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β s... | |||
TMPK-00943 | PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His)
PDGF R alpha/PDGFRA Protein, Cynomolgus, Recombinant (His)
|
Cynomolgus | HEK293 Cells |
Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. Th... | |||
TMPK-01050 | PDGF R beta/CD140b Protein, Canine, Recombinant (His)
PDGF R beta/CD140b Protein, Canine, Recombinant (His)
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Canine | HEK293 Cells |
PDGF R beta/CD140b Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 57.25 kDa and the ... | |||
TMPY-00385 | PDGFRB Protein, Rhesus, Recombinant (hFc)
PDGFRB Protein, Rhesus, Recombinant (hFc)
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Rhesus | HEK293 Cells |
PDGFRB Protein, Rhesus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.3 kDa and the accession numbe... | |||
TMPY-00900 | PDGFRA Protein, Human, Recombinant (hFc)
PDGFRA Protein, Human, Recombinant (hFc)
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Human | HEK293 Cells |
PDGFRA Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.9 kDa and the accession number... | |||
TMPY-01207 | PDGFRB Protein, Human, Recombinant (His)
PDGFRB Protein, Human, Recombinant (His)
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Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number... | |||
TMPY-03140 | PDGFRB Protein, Rat, Recombinant (His)
PDGFRB Protein, Rat, Recombinant (His)
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Rat | HEK293 Cells |
PDGFRB Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number i... | |||
TMPY-03474 | PDGFRB Protein, Rat, Recombinant (hFc)
PDGFRB Protein, Rat, Recombinant (hFc)
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Rat | HEK293 Cells |
PDGFRB Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number i... | |||
TMPY-03590 | PDGFRB Protein, Rhesus, Recombinant (His)
PDGFRB Protein, Rhesus, Recombinant (His)
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Rhesus | HEK293 Cells |
PDGFRB Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession numbe... | |||
TMPY-03825 | PDGFRA Protein, Rat, Recombinant (His)
PDGFRA Protein, Rat, Recombinant (His)
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Rat | HEK293 Cells |
PDGFRA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the accession number i... | |||
TMPY-03919 | PDGFRA Protein, Rat, Recombinant (hFc)
PDGFRA Protein, Rat, Recombinant (hFc)
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Rat | HEK293 Cells |
PDGFRA Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.2 kDa and the accession number i... | |||
TMPY-04937 | PDGFRB Protein, Human, Recombinant (His), Biotinylated
PDGFRB Protein, Human, Recombinant (His), Biotinylated
|
Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.6 kDa and the ac... | |||
TMPY-05358 | PDGFRB Protein, Human, Recombinant
PDGFRB Protein, Human, Recombinant
|
Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 56.2 kDa and the accession number is P09619-1. | |||
TMPY-05497 | PDGFRB Protein, Human, Recombinant (hFc)
PDGFRB Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
PDGFRB Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 82.8 kDa and the accession number... | |||
TMPY-05608 | PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
PDGFRA Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 59.4 ... | |||
TMPY-05787 | PDGFRA Protein, Mouse, Recombinant (His)
PDGFRA Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 Cells |
PDGFRA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.87 kDa and the accession numbe... |