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Platelet-Derived Growth Factor Receptors, PDGFRs

Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes. Examination of the different signaling cascades induced by RTKs established Ras/MAPK, PI3K, and phospholipase-γ (PLCγ) pathways as key downstream mediators of PDGFR signaling. In addition, reactive oxygen species (ROS)-dependent STAT3 activation has been established to be a key downstream mediator of PDGFR signaling in vascular smooth muscle cells.

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Species
Canine (1)
Cynomolgus (3)
Human (11)
Mouse (2)
Rat (4)
Rhesus (2)
Expression System
HEK293 Cells (23)
Tag
Avi (1)
C-His (11)
C-His-Avi (4)
C-hFc (6)
His (1)
Tag Free (1)
Cat No. product name / Synonyms Species Expression System
TMPY-05789 PDGFRA Protein, Mouse, Recombinant (hFc)
PDGFRA Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
PDGFRA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.15 kDa and the accession numbe...
TMPY-06921 PDGFRA Protein, Cynomolgus, Recombinant (His)
PDGFRA Protein, Cynomolgus, Recombinant (His)
Cynomolgus HEK293 Cells
PDGFRA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.68 kDa and the accession ...
TMPY-01139 PDGFRA Protein, Human, Recombinant (His)
PDGFRA Protein, Human, Recombinant (His)
Human HEK293 Cells
PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number...
PDGFRA Protein, Mouse, Recombinant (hFc)
TMPY-05789
PDGFRA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.15 kDa and the accession numbe...
PDGFRA Protein, Cynomolgus, Recombinant (His)
TMPY-06921
PDGFRA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.68 kDa and the accession ...
PDGFRA Protein, Human, Recombinant (His)
TMPY-01139
PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number...
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TargetMol