Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGF-R, alpha and beta each encoded by a different gene. Depending on which growth factor is bound, PDGF-R homo- or heterodimerizes. Examination of the different signaling cascades induced by RTKs established Ras/MAPK, PI3K, and phospholipase-γ (PLCγ) pathways as key downstream mediators of PDGFR signaling. In addition, reactive oxygen species (ROS)-dependent STAT3 activation has been established to be a key downstream mediator of PDGFR signaling in vascular smooth muscle cells.
Cat No. | product name / Synonyms | Species | Expression System |
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TMPY-05789 | PDGFRA Protein, Mouse, Recombinant (hFc)
PDGFRA Protein, Mouse, Recombinant (hFc)
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Mouse | HEK293 Cells |
PDGFRA Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 83.15 kDa and the accession numbe... | |||
TMPY-06921 | PDGFRA Protein, Cynomolgus, Recombinant (His)
PDGFRA Protein, Cynomolgus, Recombinant (His)
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Cynomolgus | HEK293 Cells |
PDGFRA Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.68 kDa and the accession ... | |||
TMPY-01139 | PDGFRA Protein, Human, Recombinant (His)
PDGFRA Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
PDGFRA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.7 kDa and the accession number... |