T18515 |
Palbociclib-propargyl
|
2366269-23-8
|
98%
|
|
Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent...
|
T18641 |
SirReal1-O-propargyl
|
1862237-99-7
|
98%
|
|
SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates b...
|
T18599 |
PROTAC BRD4-binding moiety 1
|
2101200-10-4
|
98%
|
|
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex effici...
|
T19172 |
A-1210477-piperazinyl
|
2351218-72-7
|
98%
|
|
A-1210477-piperazinyl is a compound that specifically targets and binds to the protein myeloid cell leukemia 1 (MCL1). This compound is utilized in PROTAC techno...
|
T10734 |
CDK ligand for PROTAC
|
T10734
|
98%
|
|
CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
|
T14288 |
Androstanolone acetate
|
1164-91-6
|
98%
|
|
Androstanolone acetate is a compound that functions as an androgen ligand, specifically targeting the androgen receptor (AR). It binds to the cIAP1 ligand Bestat...
|
T13549 |
AP1867-3-(aminoethoxy)
|
2127390-15-0
|
98%
|
|
AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
|
T13915L |
PROTAC BRD9-binding moiety 1 hydrochloride
|
T13915L
|
98%
|
|
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
|
T10716 |
CCR7 Ligand 1
|
681514-83-0
|
98%
|
|
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxid...
|
T17733 |
ATRA-hydroxyimino
|
135325-47-2
|
98%
|
|
ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifical...
|
T18593 |
GNF5-amido-Me
|
778277-37-5
|
98%
|
|
GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1].
|
T13765 |
MAK683-CH2CH2COOH
|
2639882-68-9
|
98%
|
|
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design ...
|
T17931 |
EED226-COOH
|
T17931
|
98%
|
|
EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating...
|
T18594 |
HG-7-85-01-Decyclopropane
|
T18594
|
98%
|
|
Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the for...
|
T13696 |
FN-1501-propionic acid
|
2408642-48-6
|
98%
|
|
FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
|
T1835 |
Ibrutinib
|
936563-96-1
|
99.79%
|
|
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
|
T19301 |
DUPA
|
302941-52-2
|
99.56%
|
|
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expr...
|
T12551 |
PROTAC BRD4 ligand-1
|
2313230-51-0
|
99.48%
|
|
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
|
T2066 |
Quizartinib
|
950769-58-1
|
99.42%
|
|
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
|
T12186 |
Navitoclax-piperazine
|
2143096-93-7
|
99.11%
|
|
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
|