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Ligand for Target Protein for PROTAC

Cat. No. Product name CAS No. Purity Chemical Structure
T18515 Palbociclib-propargyl 2366269-23-8 98%
Palbociclib-propargyl
Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent...
T18641 SirReal1-O-propargyl 1862237-99-7 98%
SirReal1-O-propargyl
SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates b...
T18599 PROTAC BRD4-binding moiety 1 2101200-10-4 98%
PROTAC BRD4-binding moiety 1
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex effici...
T19172 A-1210477-piperazinyl 2351218-72-7 98%
A-1210477-piperazinyl
A-1210477-piperazinyl is a compound that specifically targets and binds to the protein myeloid cell leukemia 1 (MCL1). This compound is utilized in PROTAC techno...
T10734 CDK ligand for PROTAC T10734 98%
CDK ligand for PROTAC
CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
T14288 Androstanolone acetate 1164-91-6 98%
Androstanolone acetate
Androstanolone acetate is a compound that functions as an androgen ligand, specifically targeting the androgen receptor (AR). It binds to the cIAP1 ligand Bestat...
T13549 AP1867-3-(aminoethoxy) 2127390-15-0 98%
AP1867-3-(aminoethoxy)
AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
T13915L PROTAC BRD9-binding moiety 1 hydrochloride T13915L 98%
PROTAC BRD9-binding moiety 1 hydrochloride
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
T10716 CCR7 Ligand 1 681514-83-0 98%
CCR7 Ligand 1
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxid...
T17733 ATRA-hydroxyimino 135325-47-2 98%
ATRA-hydroxyimino
ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifical...
T18593 GNF5-amido-Me 778277-37-5 98%
GNF5-amido-Me
GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1].
T13765 MAK683-CH2CH2COOH 2639882-68-9 98%
MAK683-CH2CH2COOH
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design ...
T17931 EED226-COOH T17931 98%
EED226-COOH
EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating...
T18594 HG-7-85-01-Decyclopropane T18594 98%
HG-7-85-01-Decyclopropane
Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the for...
T13696 FN-1501-propionic acid 2408642-48-6 98%
FN-1501-propionic acid
FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
T1835 Ibrutinib 936563-96-1 99.79%
Ibrutinib
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
T19301 DUPA 302941-52-2 99.56%
DUPA
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expr...
T12551 PROTAC BRD4 ligand-1 2313230-51-0 99.48%
PROTAC BRD4 ligand-1
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
T2066 Quizartinib 950769-58-1 99.42%
Quizartinib
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
T12186 Navitoclax-piperazine 2143096-93-7 99.11%
Navitoclax-piperazine
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
Palbociclib-propargyl
T18515
Palbociclib-propargyl, a PROTAC ligand targeting the protein CDK6, connects to the CRBN ligand through a PEG linker to form PROTAC CP-10. CP-10 exhibits a potent...
SirReal1-O-propargyl
T18641
SirReal1-O-propargyl, a moiety based on SirReal1, is a selective and highly potent inhibitor of Sirtuin 2 (Sirt2), demonstrating an IC50 of 2.4 μM. It operates b...
PROTAC BRD4-binding moiety 1
T18599
PROTAC BRD4-binding moiety 1 is a BRD4 ligand that binds to the cereblon ligand through a linker, enabling the formation of a PROTAC complex. This complex effici...
A-1210477-piperazinyl
T19172
A-1210477-piperazinyl is a compound that specifically targets and binds to the protein myeloid cell leukemia 1 (MCL1). This compound is utilized in PROTAC techno...
CDK ligand for PROTAC
T10734
CDK ligand for PROTAC is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
Androstanolone acetate
T14288
Androstanolone acetate is a compound that functions as an androgen ligand, specifically targeting the androgen receptor (AR). It binds to the cIAP1 ligand Bestat...
AP1867-3-(aminoethoxy)
T13549
AP1867-3-(aminoethoxy) is a synthetic ligand for FKBP and can be used in the synthesis of PROTAC FKBP12 F36V degrader.
PROTAC BRD9-binding moiety 1 hydrochloride
T13915L
PROTAC BRD9-binding moiety 1 hydrochloride binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
CCR7 Ligand 1
T10716
CCR7 Ligand 1 (CCR7-Cmp2105) is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxid...
ATRA-hydroxyimino
T17733
ATRA-hydroxyimino, also known as CRABP-II ligand 1, is a chemical compound derived from Retinoic acid (ATRA). This compound binds to the cIAP1 ligand, specifical...
GNF5-amido-Me
T18593
GNF5-amido-Me, the moiety based on GNF5 (ABL inhibitor),binds through a linker to the IAP ligand forming SNIPER[1].
MAK683-CH2CH2COOH
T13765
MAK683-CH2CH2COOH binds to EED (embryonic ectoderm development protein). MAK683-CH2CH2COOH and a VHL ligand for the E3 ubiquitin ligase have been used to design ...
EED226-COOH
T17931
EED226-COOH, derived from EED226, serves as a ligand targeting the EED protein for PROTAC applications. It attaches to a VHL ligand through a linker, culminating...
HG-7-85-01-Decyclopropane
T18594
Decyclopropane, also known as HG-7-85-01, is a chemical compound with ABL inhibitor properties. It binds to the IAP ligand through a linker, resulting in the for...
FN-1501-propionic acid
T13696
FN-1501-propionic acid, a CDK2/9 ligand, in conjunction with a CRBN ligand, has been utilized in the design of a PROTAC CDK2/9 degrader.
Ibrutinib
T1835
Ibrutinib (PCI-32765) is an irreversible inhibitor of BTK (IC50: 0.5 nM) that selectively blocks B cell activation.
DUPA
T19301
DUPA (N,N''-Carbonylbis[L-glutamic acid]) is used as the targeting moiety to actively deliver DTX for treatment of Prostate-Specific Membrane Antigen (PSMA) expr...
PROTAC BRD4 ligand-1
T12551
PROTAC BRD4 ligand-1 is a ligand for BRD4 for Protac GNE-987 and an inhibitor of BET.
Quizartinib
T2066
Quizartinib (AC220) is an inhibitor of FLT3 (Kd: 1.6 nM) and demonstrates high selectivity for FLT3 when tested against a panel of 227 additional kinases.
Navitoclax-piperazine
T12186
Navitoclax-piperazine (ABT-263-piperazine) is an inhibitor of B-cell lymphoma extra large (BCL-XL).
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TargetMol