T18601 |
Desmethyl-QCA276
|
2126819-55-2
|
98%
|
|
Desmethyl-QCA276, the QCA276-based moiety, binds to cereblon ligand via a linker to form PROTAC to degrade BET. QCA276 is a BET inhibitor with an IC50 of 10 nM, ...
|
T18650 |
Ch55-O-C3-NH2
|
144298-98-6
|
98%
|
|
Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR. Through a linker, Ch55-O-C3-NH2 interacts wi...
|
T13843 |
PROTAC IRAK4 ligand-1
|
2357108-39-3
|
98%
|
|
PROTAC IRAK4 ligand-1 is a synthetic ligand for interleukin-1 receptor-associated kinase 4.
|
T10320 |
Androgen receptor antagonist 1
|
1338812-36-4
|
98%
|
|
Androgen receptor antagonist 1 is an orally available full androgen receptor antagonist (IC50: 59 nM). It can be used in the synthesis of PROTAC AR degraders, wh...
|
T13888 |
SLF
|
195513-96-3
|
98%
|
|
SLF is a synthetic ligand for FK506-binding protein (FKBP)( with an affinity of 3.1 μM for FKBP51 and an IC50 of 0.22 μM for FKBP12). SLF can be used in the synt...
|
T10345 |
Apcin-A
|
1683617-62-0
|
98%
|
|
Apcin-A is an anaphase-promoting complex (APC) inhibitor. It interacts strongly with Cdc20 and inhibits the ubiquitination of Cdc20 substrates. Apcin-A can be us...
|
T12558 |
PROTAC BET-binding moiety 2
|
916493-82-8
|
98%
|
|
PROTAC BET-binding moiety 2 is an BET bromodomain inhibitor.
|
T12905 |
SI-109
|
T12905
|
98%
|
|
SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
|
T17940 |
Estrone-N-O-C1-amido
|
138219-84-8
|
98%
|
|
Estrone-N-O-C1-amido (ERα ligand 1) is an estrogen ligand derived from Estrone that specifically binds to estrogen receptor α (ERα). Through a linker, Estrone-N-...
|
T10734L |
CDK ligand for PROTAC hydrochloride
|
T10734L
|
98%
|
|
CDK ligand for PROTAC hydrochloride is a CDK inhibitor with antitumor activity. It has been used to design PROTAC CDK4/6 degraders.
|
T13841 |
PROTAC Her3-binding moiety 1
|
1603845-36-8
|
98%
|
|
PROTAC Her3-binding moiety 1 is a Her3 Ligand for PROTAC.
|
T13086 |
I-BET762 carboxylic acid
|
1300019-38-8
|
98%
|
|
I-BET762 carboxylic acid is an inhibitor of BRD4(pIC50 of 5.1).
|
T12557 |
PROTAC BET-binding moiety 1
|
2093387-77-8
|
98%
|
|
PROTAC BET-binding moiety 1 is a key intermediate in the synthesis of high affinity BET inhibitors
|
T18053 |
Ipatasertib-NH2
|
1001382-14-4
|
98%
|
|
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), ...
|
T13914 |
SLF-amido-C2-COOH
|
1092369-24-8
|
98%
|
|
SLF-amido-C2-COOH is a synthetic ligand for FKBP (SLF), and can be used in the synthesis of PROTACs.
|
T18611 |
AP1867-2-(carboxymethoxy)
|
2230613-03-1
|
98%
|
|
AP1867-2-(carboxymethoxy), a moiety based on the synthetic FKBP12F36V-directed ligand AP1867, connects to the CRBN ligand through a linker to generate dTAG molec...
|
T13915 |
PROTAC BRD9-binding moiety 1
|
2097512-23-5
|
98%
|
|
PROTAC BRD9-binding moiety 1 that binds to BRD9, and used for inhibiting BRD9 activity, based on PROTAC.
|
T18592 |
Imatinib carbaldehyde
|
1436868-85-7
|
98%
|
|
Imatinib carbaldehyde (also known as CGP-57148B carbaldehyde) is a compound derived from Imatinib, an inhibitor of the ABL protein. Imatinib carbaldehyde binds t...
|
T10743 |
CDK9-IN-11
|
2748368-15-0
|
98%
|
|
CDK9-IN-11 is a potent CDK9 inhibitor that is the ligand for the PROTAC CDK9 Degrader-1 [1].
|
T10522 |
BET-IN-6
|
2570470-39-0
|
98%
|
|
BET-IN-6, a ligand with potent and high affinity for inhibiting BRD2/BRD4, plays a crucial role in the synthesis of PROTAC BRD2/BRD4 degrader-1 [1], targeting th...
|