The terpenoids, sometimes called isoprenoids, are a large and diverse class of naturally occurring organic chemicals derived from terpenes. Most are multicyclic structures with oxygen-containing functional groups. About 60% of known natural products are terpenoids.
Plant terpenoids are used for their aromatic qualities and play a role in traditional herbal remedies. Terpenoids contribute to the scent of eucalyptus, the flavors of cinnamon, cloves, and ginger, the yellow color in sunflowers, and the red color in tomatoes. Well-known terpenoids include citral, menthol, camphor, salvinorin A in the plant Salvia divinorum, the cannabinoids found in cannabis, ginkgolide and bilobalide found in Ginkgo biloba, and the curcuminoids found in turmeric and mustard seed.
Many terpenes have biological activities and are used for the treatment of human diseases. The worldwide sales of terpene-based pharmaceuticals in 2002 were approximately US $12 billion. Among these pharmaceuticals, the anticancer drug Taxol and the antimalarial drug Artimesinin are two of the most renowned terpene-based drugs. All terpenoids are synthesized from two five-carbon building blocks. Based on the number of the building blocks, terpenoids are commonly classified as monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), and sesterterpenes (C25). These terpenoids display a wide range of biological activities against cancer, malaria, inflammation, and a variety of infectious diseases (viral and bacterial). In last two decades, natural-product bioprospecting from the marine environment has resulted in hundreds of terpenoids with novel structures and interesting bioactivities, with more to be discovered in the future. There is no doubt that more terpenoid-based clinical drugs will become available and will play a more significant role in human disease treatment in the near future.
Cat. No. | Product name | CAS No. | Purity | Chemical Structure |
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TN1140 | Onjisaponin B | 35906-36-6 | 99.88% |
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Onjisaponin B induces autophagy via the AMPK-mTOR signaling pathway, increases the NGF level and accelerates both the removal of mutant huntingtin and A53T α±-sy... | ||||
T8280 | Deacetylasperulosidic Acid | 14259-55-3 | 99.88% |
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Deacetylasperulosidic Acid is a natural compound of Morinda citrifolia fruit. It has antioxidant activity by increasing superoxide dismutase activity. It also pr... | ||||
T6S2246 | Alisol B 23-acetate | 26575-95-1 | 99.87% |
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1. Alisol B 23-acetate (Alisol B Acetate) produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transpo... | ||||
T10689 | Cauloside D | 12672-45-6 | 99.87% |
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Cauloside D, a triterpene glycoside isolated from Caulophyllum robustum Max, inhibits the expression of iNOS and proinflammatory cytokines with anti-inflammator... | ||||
TQ0198 | Phorbol 12-myristate 13-acetate | 16561-29-8 | 99.87% |
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Phorbol 12-myristate 13-acetate (PMA) belongs to the phorbol ester group of natural products and is an activator of PKC, SphK, and NF-κB. Phorbol 12-myristate 13... | ||||
T4S0290 | Araloside A | 7518-22-1 | 99.87% |
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Araloside A (Chikusetsusaponin IV) might relieve cutaneous symptoms caused by excessive apoptotic cell death in the skin through the Fas/FasL pathway. | ||||
TN1828 | Kahweol | 6894-43-5 | 99.86% |
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Kahweol has anticarcinogenic, anti-angiogenic,and anti-inflammatory activities, it can block the LPS-induced activation of NF-kappaB by preventing IkappaB degrad... | ||||
T3401 | Ginsenoside F1 | 53963-43-2 | 99.86% |
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Ginsenoside F1 (20(S)-Ginsenoside F1) is an enzymatically modified derivative of ginsenoside Rg1, showing competitive inhibition of the activity of CYP3A4 and a ... | ||||
TN1118 | Tormentic acid | 13850-16-3 | 99.86% |
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Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic , anti-allodynic, and hepatoprotective properties, | ||||
T16838 | Saikogenin A | 5092-09-1 | 99.86% |
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Saikogenin A is a dipeptidyl peptidase-4 inhibitor. | ||||
T2833 | Dehydrocostus Lactone | 477-43-0 | 99.86% |
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Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties. | ||||
T2894 | Norcantharidin | 5442-12-6 | 99.86% |
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Norcantharidin (Norcantharadine) is a synthetic anticancer compound which is a dual inhibitor for c-Met and EGFR in human colon cancers. | ||||
TN1634 | Euphorbia factor L7b | 93550-95-9 | 99.85% |
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Euphorbia factor L7b,a natural product obtained from the herbs of Euphorbia pekinensis Rupr. | ||||
T3793 | (20R)-Ginsenoside Rh1 | 80952-71-2 | 99.85% |
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(20R)-Ginsenoside Rh1 (20(R)-Ginsenoside Rh1) can inhibit the thrombin-induced conversion of fibrinogen to fibrin. | ||||
TN2346 | Mogrol | 88930-15-8 | 99.85% |
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Mogrol, a biometabolite of mogrosides, functions by inhibiting the ERK1/2 and STAT3 pathways, diminishing CREB activation, and activating AMPK signaling. | ||||
TN3820 | Demethoxydeacetoxypseudolaric acid B | 82508-36-9 | 99.85% |
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Demethoxydeacetoxypseudolaric acid B's the metabolic reaction of TDA in vivo is mainly occurred in blood and contributes to be the hydrolysis of plasma esterase ... | ||||
T5727 | CAFESTOL | 469-83-0 | 99.84% |
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CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells.... | ||||
T3829 | Ginsenoside F3 | 62025-50-7 | 99.84% |
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Ginsenoside-F3 has immunoenhancing activity by regulating production and gene expression of type 1, type 2 cytokines in murine spleen cells. Ginsenoside-F3 enhan... | ||||
T3414 | Morroniside | 25406-64-8 | 99.84% |
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Morroniside would act as a regulator of hepatic inflammatory reactions and lipid metabolism in db/db mice. It exhibits protective effects against diabetic renal ... | ||||
T6S2115 | Ginkgolide J | 107438-79-9 | 99.83% |
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Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippoca... |